Csik-Salmon J, Blais D, Vaillancourt D, Garon O, Bisaillon A
Département de biomédecine Vétérinaire, Faculté de médecine Vétérinaire, Université de Montreal, Saint-Hyacinthe, Québec.
Can J Vet Res. 1996 Oct;60(4):288-95.
Loss of rear motor control is the main limiting factor in the use of caudal epidural anesthesia in the horse. In man and laboratory animals, a small dose of an opiate combined with a local anesthetic enhances analgesia without impairing motor function. Thus, the amount of local anesthetic administered may be reduced. Butorphanol is an opiate widely used in horses. It has a good margin of safety and few cardiorespiratory effects. The effects of lidocaine (0.25 mg/kg) and lidocaine-butorphanol (0.25 mg/kg, and 0.04 mg/kg, respectively) were compared in 2 groups of 5 healthy unsedated mares. Horses in each group received either lidocaine or lidocaine-butorphanol in saline solution for a total volume of 0.0165 mg/kg. Epidural injection was performed at the first coccygeal interspace. Each mare was used only once. Cutaneous analgesia was assessed by a response to a pin prick; and visceral analgesia was assessed by response to a noxious stimulus applied to the urethra. Heart rate, respiratory rate, and arterial blood pressure were also measured. Analysis of the results showed an increase in duration of both cutaneous and visceral analgesia in the mares given lidocaine-butorphanol. Cutaneous analgesia increased from 36 +/- 13 to 150 +/- 21 min and visceral analgesia increased from 22 +/- 10 to 162 +/- 16 min. A cranial extension of the cutaneous analgesia was also observed. Cardiorespiratory depression or signs of excitation were not observed. However, these mares demonstrated peculiar walking in the hind limbs, not associated with signs of ataxia or hyperkinesia.
后肢运动控制丧失是马使用尾段硬膜外麻醉的主要限制因素。在人类和实验动物中,小剂量阿片类药物与局部麻醉药联合使用可增强镇痛效果而不损害运动功能。因此,可减少局部麻醉药的用量。布托啡诺是一种在马中广泛使用的阿片类药物。它具有良好的安全范围,对心肺的影响较小。在两组各5匹未镇静的健康母马中比较了利多卡因(0.25mg/kg)和利多卡因 - 布托啡诺(分别为0.25mg/kg和0.04mg/kg)的效果。每组马在盐溶液中接受利多卡因或利多卡因 - 布托啡诺,总体积为0.0165mg/kg。在第一尾椎间隙进行硬膜外注射。每匹母马仅使用一次。通过对针刺的反应评估皮肤镇痛;通过对施加于尿道的有害刺激的反应评估内脏镇痛。还测量了心率、呼吸频率和动脉血压。结果分析表明,给予利多卡因 - 布托啡诺的母马皮肤和内脏镇痛持续时间均增加。皮肤镇痛从36±13分钟增加到150±21分钟,内脏镇痛从22±10分钟增加到162±16分钟。还观察到皮肤镇痛向头侧延伸。未观察到心肺抑制或兴奋迹象。然而,这些母马后肢出现特殊行走,与共济失调或运动亢进迹象无关。