Department of Medicine, Section of Pulmonary, Montefiore Medical Center, Albert Einstein College of Medicine, Centennial Building Suite 423, Bronx, NY 10467, USA.
Clin Chest Med. 2009 Sep;30(3):455-65, vii. doi: 10.1016/j.ccm.2009.05.012.
Obstructive sleep apnea is a common disorder, and obesity is a known risk factor for its development. The prevalence of obesity is increasing worldwide, and a corresponding increase in the prevalence of obstructive sleep apnea and its cardiovascular and noncardiovascular consequences is likely. This article reviews the established evidence supporting obesity as a risk factor for obstructive sleep apnea and discusses the evidence suggesting that obesity is also a consequence of obstructive sleep apnea. There is evidence that treating obesity reduces the severity of obstructive sleep apnea and that treating obstructive sleep apnea decreases obesity. However, the evidence does not support a sustained correlation between weight loss and improvement in sleep-disordered breathing.
阻塞性睡眠呼吸暂停是一种常见疾病,肥胖是其发展的已知危险因素。肥胖在全球范围内的流行率正在增加,阻塞性睡眠呼吸暂停及其心血管和非心血管后果的流行率也可能相应增加。本文综述了支持肥胖是阻塞性睡眠呼吸暂停危险因素的既定证据,并讨论了肥胖也是阻塞性睡眠呼吸暂停后果的证据。有证据表明,治疗肥胖可以降低阻塞性睡眠呼吸暂停的严重程度,治疗阻塞性睡眠呼吸暂停可以降低肥胖。然而,证据并不支持体重减轻与睡眠呼吸障碍改善之间存在持续相关性。