Lee H S, Kim M S, Kim M H, Kim Y J, Kim W Y
Department of Sports Science, Seoul Sports Graduate University, Seoul, Korea.
Eur J Clin Nutr. 2006 Sep;60(9):1130-5. doi: 10.1038/sj.ejcn.1602429. Epub 2006 Apr 26.
The purpose of this study was to assess the prevalence of iron deficiency anemia among Korean pregnant women and to assess the association between maternal hemoglobin (Hb) level and pregnancy outcome.
A longitudinal study.
Ewha Womans University Hospital, Seoul, Korea.
A total of 248 normal pregnant women of 24-28 weeks gestation and 190 babies born to the pregnant subjects.
Maternal anthropometry, blood parameters and pregnancy outcomes were measured.
Mean Hb, serum iron concentration, transferrin saturation and total iron binding capacity of the subjects were 11.4 g/dl, 89.4 microg/dl, 18.7% and 484.6 microg/dl, respectively, and 30.2% of the subjects were anemic judged by Hb concentration of <10.5 g/dl. When subjects were classified into tertile groups based on Hb levels, the lowest tertile (HbT1) group had significantly lower concentrations of cord serum iron and albumin than those in the highest tertile (HbT3) group. Newborn infants from the HbT1 group had significantly higher rates of preterm delivery, low birth weight and low Apgar scores than those in other groups. Logistic regression analysis showed that maternal serum albumin and Hb level were the most important predictive variables for low birth weight.
A substantial proportion of Korean pregnant women were at risk of anemia. Infants born to women with a low Hb level showed a lower birth weight, height and Apgar scores.
本研究旨在评估韩国孕妇缺铁性贫血的患病率，并评估孕妇血红蛋白（Hb）水平与妊娠结局之间的关联。
一项纵向研究。
韩国首尔梨花女子大学医院。
共有248名妊娠24 - 28周的正常孕妇以及这些孕妇所生的190名婴儿。
测量孕妇人体测量学指标、血液参数和妊娠结局。
研究对象的平均Hb、血清铁浓度、转铁蛋白饱和度和总铁结合力分别为11.4 g/dl、89.4 μg/dl、18.7%和484.6 μg/dl，根据Hb浓度<10.5 g/dl判断，30.2%的研究对象贫血。当根据Hb水平将研究对象分为三分位数组时，最低三分位数（HbT1）组的脐血清铁和白蛋白浓度显著低于最高三分位数（HbT3）组。HbT1组的新生儿早产、低出生体重和低阿氏评分发生率显著高于其他组。逻辑回归分析表明，孕妇血清白蛋白和Hb水平是低出生体重最重要的预测变量。
相当比例的韩国孕妇有贫血风险。Hb水平低的女性所生婴儿出生体重、身高和阿氏评分较低。
