Tawfik A F
Department of Pharmaceutics and Microbiology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
J Chemother. 1991 Aug;3(4):226-31. doi: 10.1080/1120009x.1991.11739095.
Vancomycin, teicoplanin, daptomycin, and coumermycin were investigated for immunomodulatory activity on both humoral and cell-mediated immune responses in Balb/c mice. All four antibiotics did not produce any interference with these responses as measured by hemolytic plaque assay and delayed-type hypersensitivity to sheep red blood cells. The administration of these antibiotics for seven days did not affect the peripheral blood leukocyte count or spleen weights. When these antibiotics were tested for their interaction with human polymorphonuclear phagocytic activity, no alteration in this activity was observed. These findings suggest that vancomycin, teicoplanin, daptomycin, and coumermycin may be safely used for the treatment of infections without altering host-defence mechanisms.
研究了万古霉素、替考拉宁、达托霉素和香豆霉素对Balb/c小鼠体液免疫和细胞介导免疫反应的免疫调节活性。通过溶血空斑试验和对绵羊红细胞的迟发型超敏反应测定，这四种抗生素均未对这些反应产生任何干扰。连续七天给予这些抗生素不影响外周血白细胞计数或脾脏重量。当测试这些抗生素与人多形核吞噬细胞活性的相互作用时，未观察到该活性有改变。这些发现表明，万古霉素、替考拉宁、达托霉素和香豆霉素可安全用于治疗感染，而不会改变宿主防御机制。
