Bomzon Arieh
Department of Pharmacology, Bruce and Ruth Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa.
Comp Med. 2006 Apr;56(2):114-8.
Buprenorphine is a widely used analgesic for relief of postoperative pain in rats. The effect of repeated doses of buprenorphine throughout the postoperative pain and stress response is unknown. This investigation tested the hypotheses that (a) daily analgesic doses of buprenorphine for 7 d ameliorate the stress response after laparotomy in rats and (b) preoperative buprenorphine better ameliorates the response than do peri- and postoperative administration. Postoperative effects on body weight, daily food and water consumption, and daily fecal and urinary outputs were monitored in groups of rats treated for 7 d with analgesic doses of buprenorphine initiated at different time points relative to the time of laparotomy. Analgesic doses of buprenorphine had no effect on the study parameters in healthy unoperated rats. Daily injection of buprenorphine delayed the time at which the preoperative body weight was restored without decreasing the postoperative changes in daily food consumption, water intake, and fecal and urinary outputs in the operated rats. The effects of daily analgesic doses of buprenorphine for 7 d on body weight, daily food, and water consumption, and fecal and urinary outputs were minimal and less statistically significant than the changes caused by surgery itself. However, this dosing regimen seems to delay the restoration of body weight after abdominal surgery in rats.
丁丙诺啡是一种广泛用于缓解大鼠术后疼痛的镇痛药。多次给予丁丙诺啡对术后疼痛和应激反应的影响尚不清楚。本研究检验了以下假设：(a) 连续7天每日给予丁丙诺啡镇痛剂量可改善大鼠剖腹术后的应激反应；(b) 术前给予丁丙诺啡比术中和术后给予能更好地改善反应。在相对于剖腹手术时间的不同时间点开始用丁丙诺啡镇痛剂量治疗7天的大鼠组中，监测术后对体重、每日食物和水消耗量以及每日粪便和尿量的影响。丁丙诺啡的镇痛剂量对健康未手术大鼠的研究参数没有影响。每日注射丁丙诺啡延迟了术前体重恢复的时间，但并未降低手术大鼠术后每日食物消耗量、饮水量以及粪便和尿量的变化。连续7天每日给予丁丙诺啡镇痛剂量对体重、每日食物和水消耗量以及粪便和尿量的影响很小，且在统计学上不如手术本身引起的变化显著。然而，这种给药方案似乎会延迟大鼠腹部手术后体重的恢复。
