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急性淋巴细胞白血病中主要累及下消化道的侵袭性真菌感染的诊断困难。

Difficult diagnosis of invasive fungal infection predominantly involving the lower gastrointestinal tract in acute lymphoblastic leukaemia.

作者信息

Avcu Gulhadiye, Karapinar Deniz Yilmaz, Yazici Pinar, Duyu Muhterem, Polat Suleyha Hilmioglu, Atabay Berna, Doganavsargil Basak, Karapinar Bulent

机构信息

Department of Pediatric Infectious Diseases, Ege University, Faculty of Medicine, Izmir 35040, Turkey.

Department of Pediatric Hematology, Ege University, Faculty of Medicine, Izmir 35040, Turkey.

出版信息

Med Mycol Case Rep. 2016 Jan 30;11:1-4. doi: 10.1016/j.mmcr.2016.01.005. eCollection 2016 Mar.

DOI:10.1016/j.mmcr.2016.01.005
PMID:26937339
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4752813/
Abstract

Invasive fungal infections are most commonly seen in immunocompromised patients and usually affect the respiratory system. Gastrointestinal system involvement of mucormycosis and invasive aspergillosis is rarely reported in childhood. Here we describe a 5 year old boy with acute lymphoblastic leukaemia who developed invasive fungal infection particularly affecting the lower gastrointestinal system to emphasise the difficulties in diagnosis and management of invasive fungal infections in immunocompromised patients.

摘要

侵袭性真菌感染最常见于免疫功能低下的患者，通常累及呼吸系统。毛霉菌病和侵袭性曲霉菌病累及胃肠道系统在儿童中鲜有报道。在此，我们描述一名5岁患急性淋巴细胞白血病的男孩，他发生了侵袭性真菌感染，尤其累及下胃肠道系统，以强调免疫功能低下患者侵袭性真菌感染在诊断和管理方面的困难。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b127/4752813/97bb6e7f178f/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b127/4752813/7a09a4762783/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b127/4752813/5e5c0fd71e5a/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b127/4752813/00d7690b5d89/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b127/4752813/b71c3c47c71d/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b127/4752813/97bb6e7f178f/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b127/4752813/7a09a4762783/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b127/4752813/5e5c0fd71e5a/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b127/4752813/00d7690b5d89/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b127/4752813/b71c3c47c71d/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b127/4752813/97bb6e7f178f/gr5.jpg

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本文引用的文献

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J Med Case Rep. 2014 Dec 5;8:407. doi: 10.1186/1752-1947-8-407.
2
Invasive coinfection with Aspergillus and Mucor in a patient with acute myeloid leukemia.急性髓系白血病患者侵袭性曲霉和毛霉合并感染。
Clin Drug Investig. 2013 Feb;33 Suppl 1:S51-5. doi: 10.1007/s40261-012-0022-4.
3
Fungal infections in leukemia patients: how do we prevent and treat them?白血病患者的真菌感染：我们如何预防和治疗？
患者因侵袭性曲霉病导致多处小肠穿孔：病例报告及文献系统回顾。
Infection. 2018 Jun;46(3):317-324. doi: 10.1007/s15010-018-1115-7. Epub 2018 Jan 22.
Clin Infect Dis. 2010 Feb 1;50(3):405-15. doi: 10.1086/649879.
4
Primary gastrointestinal aspergillosis after autologous peripheral blood progenitor cell transplantation: an unusual presentation of invasive aspergillosis.自体外周血祖细胞移植后原发性胃肠道曲霉病：侵袭性曲霉病的一种不寻常表现。
Transpl Infect Dis. 2008 Jun;10(3):193-6. doi: 10.1111/j.1399-3062.2007.00288.x. Epub 2007 Dec 7.
5
Invasive aspergillosis localised to the colon presenting as toxic megacolon.侵袭性曲霉菌病局限于结肠，表现为中毒性巨结肠。
Eur J Haematol. 2007 Mar;78(3):270-3. doi: 10.1111/j.1600-0609.2006.00812.x.
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