体重指数较高的学龄男孩的严重气道高反应性
Severe airway hyperresponsiveness in school-aged boys with a high body mass index.
作者信息
Jang An-Soo, Lee June Huk, Park Sung Woo, Shin Mee Yong, Kim Do Jin, Park Choon-Sik
机构信息
Asthma and Allergy Research Group, Allergy and Respiratory Diseases, Pediatrics, Soonchunhyang University Hospital, Bucheon, Korea.
出版信息
Korean J Intern Med. 2006 Mar;21(1):10-4. doi: 10.3904/kjim.2006.21.1.10.
BACKGROUND
An association between obesity and asthma has been reported. The prevalence of airway hyperresponsiveness (AHR), results of skin prick tests, body mass index (BMI), and asthma symptoms were examined in schoolchildren.
METHODS
The results of BMI (kg/m2) determination, skin prick testing, spirometry, asthma questionnaires, and methacholine challenge tests were obtained in a cross-sectional survey of 667 schoolchildren. The methacholine concentration causing a 20% fall in FEV1 (PC20) was used as the threshold of AHR. If the PC20 was less than 16 mg/mL, the subject was considered to have methachloine mediated AHR.
RESULTS
The mean BMI was 17.1 +/- 0.09 kg/m2. The prevalence of AHR was 42.70%. The sensitization rate to common inhalant allergens was 30.3%. PC20 in children with BMIs > or = 17.1 kg/m2 was significantly lower than that in children with BMIs 17.1 kg/m2. The mean BMIs of boys and girls were not significantly different. The levels of PC20 by sex were not different. The children were grouped by sex into percentile of BMI. PC20 in boys was lower in the obese group than in the non-weight and overweight groups (p<0.05). PC20 in boys and girls with atopy was significantly lower than in those without atopy. In a multiple logistic regression model that included all of the children and adjusted for confounding variables, independent associations with AHR were seen with BMI, asthma symptoms, and atopy.
CONCLUSIONS
BMI had an association with AHR in school-age boys.
背景
已有报道称肥胖与哮喘之间存在关联。对学童的气道高反应性（AHR）患病率、皮肤点刺试验结果、体重指数（BMI）及哮喘症状进行了研究。
方法
在一项对667名学童的横断面调查中，获取了BMI（kg/m²）测定结果、皮肤点刺试验、肺功能测定、哮喘问卷及乙酰甲胆碱激发试验结果。使第一秒用力呼气容积（FEV₁）下降20%的乙酰甲胆碱浓度（PC20）用作AHR的阈值。如果PC20小于16mg/mL，则该受试者被认为存在乙酰甲胆碱介导的AHR。
结果
平均BMI为17.1±0.09kg/m²。AHR患病率为42.70%。对常见吸入性过敏原的致敏率为30.3%。BMI≥17.1kg/m²的儿童的PC20显著低于BMI<17.1kg/m²的儿童。男孩和女孩的平均BMI无显著差异。按性别划分的PC20水平无差异。根据性别将儿童按BMI百分位数分组。肥胖组男孩的PC20低于非体重增加和超重组（p<0.05）。有特应性的男孩和女孩的PC20显著低于无特应性的儿童。在纳入所有儿童并对混杂变量进行校正的多元逻辑回归模型中，发现BMI、哮喘症状和特应性与AHR存在独立关联。
结论
BMI与学龄期男孩的AHR有关联。
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