Inouye Shigeharu, Uchida Katsuhisa, Takizawa Toshio, Yamaguchi Hideyo, Abe Shigeru
Teikyo University Institute of Medical Mycology, 256 Otsuka, Hachioji, Tokyo 192-0395, Japan.
J Infect Chemother. 2006 Apr;12(2):100-4. doi: 10.1007/s10156-005-0427-6.
The antimicrobial activity against two bacterial strains and three fungi of five terpenoid quinones, three related quinones, and a quinone-containing essential oil was investigated by broth dilution and by agar vapor and box vapor assays. All the quinones, except for coenzyme Q10, exhibited their highest activity against Trichophyton mentagrophytes. Thymoquinone showed the most potent activity, not only by solution contact but also by vapor contact, with menadione the next most potent. Alizarin showed high activity only by solution contact. The antibacterial activity was related to the orthoquinone structure (1,2-chloranil and 1,2-naphthoquinone) and the antifungal activity was related to the paraquinone structure (chloranil, ubiquinone 0, thymoquinone, and menadione).
通过肉汤稀释法以及琼脂蒸汽和箱式蒸汽试验，研究了五种萜类醌、三种相关醌和一种含醌精油对两种细菌菌株及三种真菌的抗菌活性。除辅酶Q10外，所有醌类对须癣毛癣菌均表现出最高活性。百里醌不仅通过溶液接触，而且通过蒸汽接触表现出最强活性，甲萘醌次之。茜素仅通过溶液接触表现出高活性。抗菌活性与邻醌结构（1,2 - 氯醌和1,2 - 萘醌）有关，而抗真菌活性与对醌结构（氯醌、泛醌0、百里醌和甲萘醌）有关。
