VandeWoude S J, Luzarraga M B
Johns Hopkins University School of Medicine, Baltimore, MD.
Lab Anim Sci. 1991 Oct;41(5):401-6.
During a 15-month period, 25 cynomolgus macaques (Macaca fascicularis) at the Johns Hopkins University were observed to have nasal discharge. Fifteen (60%) of these animals had positive nasal cultures for Branhamella catarrhalis. Clinical signs associated with infection by this bacterium were sneezing, epistaxis, and mucohemorrhagic nasal discharge. Treatment with antibiotics resulted in prompt resolution of clinical signs. Post-therapeutic nasal cultures were negative for B. catarrhalis. Two groups of clinically normal, culture-negative, cynomolgus macaques were inoculated with natural isolates of B. catarrhalis which had been passaged in culture for various amounts of time. Five of the eight animals inoculated became culture-positive and had mild nasal discharge. Presence of blood on nasal swabs was indicative of infection with B. catarrhalis. Three of the inoculated animals had post-swabbing epistaxis. This report documents the role of B. catarrhalis as an upper respiratory pathogen in the cynomolgus monkey which causes mild self-limiting disease reminiscent of the so-called "Bloody-Nose Syndrome." In addition to the obvious clinical significance of this finding to primate clinicians, development of an animal model for human disease caused by this organism may be possible.
在15个月的时间里，约翰·霍普金斯大学的25只食蟹猴（猕猴属）出现了鼻腔分泌物。其中15只（60%）动物的鼻腔培养物中卡他布兰汉菌呈阳性。与这种细菌感染相关的临床症状包括打喷嚏、鼻出血和黏液出血性鼻腔分泌物。使用抗生素治疗后临床症状迅速缓解。治疗后的鼻腔培养物中卡他布兰汉菌呈阴性。两组临床正常、培养阴性的食蟹猴接种了在培养基中传代不同时间的卡他布兰汉菌自然分离株。接种的8只动物中有5只培养物呈阳性，并出现轻度鼻腔分泌物。鼻拭子上有血表明感染了卡他布兰汉菌。3只接种动物在擦拭后出现鼻出血。本报告记录了卡他布兰汉菌作为食蟹猴上呼吸道病原体的作用，它会引起轻度自限性疾病，类似于所谓的“鼻出血综合征”。除了这一发现对灵长类动物临床医生具有明显的临床意义外，开发由这种病原体引起的人类疾病的动物模型也有可能。
