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2
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本文引用的文献

1
Membrane potential and gentamicin uptake in Staphylococcus aureus.金黄色葡萄球菌的膜电位与庆大霉素摄取
Proc Natl Acad Sci U S A. 1982 Nov;79(21):6693-7. doi: 10.1073/pnas.79.21.6693.
2
Quantitative association between electrical potential across the cytoplasmic membrane and early gentamicin uptake and killing in Staphylococcus aureus.金黄色葡萄球菌细胞质膜两侧的电势与早期庆大霉素摄取及杀菌作用之间的定量关联。
J Bacteriol. 1984 Mar;157(3):863-7. doi: 10.1128/jb.157.3.863-867.1984.
3
The use of valinomycin, nigericin and trichlorocarbanilide in control of the protonmotive force in Escherichia coli cells.缬氨霉素、尼日利亚菌素和三氯卡班在控制大肠杆菌细胞质子动力中的应用。
Biochem J. 1983 Apr 15;212(1):105-12. doi: 10.1042/bj2120105.
4
Transport of protons across membranes by weak acids.弱酸介导的质子跨膜转运
Physiol Rev. 1980 Jul;60(3):825-63. doi: 10.1152/physrev.1980.60.3.825.
5
Mode of action of the peptide antibiotic nisin and influence on the membrane potential of whole cells and on cytoplasmic and artificial membrane vesicles.肽抗生素乳链菌肽的作用模式及其对全细胞膜电位以及细胞质膜和人工膜囊泡的影响。
Antimicrob Agents Chemother. 1985 May;27(5):841-5. doi: 10.1128/AAC.27.5.841.
6
In vitro activity and mechanism of action of A21978C1, a novel cyclic lipopeptide antibiotic.新型环脂肽抗生素A21978C1的体外活性及作用机制
Antimicrob Agents Chemother. 1985 Mar;27(3):357-62. doi: 10.1128/AAC.27.3.357.
7
The role of acyl chain character and other determinants on the bilayer activity of A21978C an acidic lipopeptide antibiotic.酰基链特性及其他决定因素对酸性脂肽抗生素A21978C双层活性的作用。
Biochim Biophys Acta. 1986 Jul 24;859(2):219-26. doi: 10.1016/0005-2736(86)90217-8.
8
Bacterial uptake of aminoglycoside antibiotics.氨基糖苷类抗生素的细菌摄取
Microbiol Rev. 1987 Dec;51(4):439-57. doi: 10.1128/mr.51.4.439-457.1987.
9
In vitro and in vivo activity of LY 146032, a new cyclic lipopeptide antibiotic.新型环脂肽抗生素LY 146032的体外和体内活性
Antimicrob Agents Chemother. 1986 Oct;30(4):532-5. doi: 10.1128/AAC.30.4.532.
10
Fluorescence indicates a calcium-dependent interaction between the lipopeptide antibiotic LY146032 and phospholipid membranes.荧光表明脂肽抗生素LY146032与磷脂膜之间存在钙依赖性相互作用。
Biochemistry. 1988 Jun 28;27(13):4639-45. doi: 10.1021/bi00413a009.

达托霉素可破坏生长中的金黄色葡萄球菌的膜电位。

Daptomycin disrupts membrane potential in growing Staphylococcus aureus.

作者信息

Alborn W E, Allen N E, Preston D A

机构信息

Infectious Disease Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285.

出版信息

Antimicrob Agents Chemother. 1991 Nov;35(11):2282-7. doi: 10.1128/AAC.35.11.2282.

DOI:10.1128/AAC.35.11.2282
PMID:1666494
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC245372/
Abstract

Daptomycin (LY146032) caused a calcium-dependent dissipation of the membrane potential (delta psi) in Staphylococcus aureus without noticeably affecting the chemical gradient (delta pH) across the membrane. The effect of daptomycin on membrane energization may account for many of the inhibitory effects on macromolecular biosyntheses and membrane function reported for this antibiotic. Our evidence indicates that the bactericidal activity of daptomycin is dependent on an available delta psi.

摘要

达托霉素（LY146032）可导致金黄色葡萄球菌膜电位（Δψ）呈钙依赖性消散，而对跨膜化学梯度（ΔpH）无明显影响。达托霉素对膜能量化的作用可能解释了该抗生素对大分子生物合成和膜功能的诸多抑制作用。我们的证据表明，达托霉素的杀菌活性依赖于有效的Δψ。