达托霉素可破坏生长中的金黄色葡萄球菌的膜电位。
Daptomycin disrupts membrane potential in growing Staphylococcus aureus.
作者信息
Alborn W E, Allen N E, Preston D A
机构信息
Infectious Disease Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285.
出版信息
Antimicrob Agents Chemother. 1991 Nov;35(11):2282-7. doi: 10.1128/AAC.35.11.2282.
Abstract
Daptomycin (LY146032) caused a calcium-dependent dissipation of the membrane potential (delta psi) in Staphylococcus aureus without noticeably affecting the chemical gradient (delta pH) across the membrane. The effect of daptomycin on membrane energization may account for many of the inhibitory effects on macromolecular biosyntheses and membrane function reported for this antibiotic. Our evidence indicates that the bactericidal activity of daptomycin is dependent on an available delta psi.
摘要
达托霉素（LY146032）可导致金黄色葡萄球菌膜电位（Δψ）呈钙依赖性消散，而对跨膜化学梯度（ΔpH）无明显影响。达托霉素对膜能量化的作用可能解释了该抗生素对大分子生物合成和膜功能的诸多抑制作用。我们的证据表明，达托霉素的杀菌活性依赖于有效的Δψ。
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