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Causes of death among women with human immunodeficiency virus infection in the era of combination antiretroviral therapy.联合抗逆转录病毒治疗时代感染人类免疫缺陷病毒的女性的死亡原因
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Prevalence and correlates of highly active antiretroviral therapy switching in the Women's Interagency HIV Study.女性机构间HIV研究中高效抗逆转录病毒治疗转换的患病率及其相关因素
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Adherence to antiretroviral therapy and its association with sexual behavior in a national sample of women with human immunodeficiency virus.在全国范围内的一组感染人类免疫缺陷病毒的女性样本中，抗逆转录病毒治疗的依从性及其与性行为的关联。
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高效抗逆转录病毒治疗（HAART）时代女性吸烟与HIV预后的关联：女性机构间HIV研究报告

Association of cigarette smoking with HIV prognosis among women in the HAART era: a report from the women's interagency HIV study.

作者信息

Feldman Joseph G, Minkoff Howard, Schneider Michael F, Gange Stephen J, Cohen Mardge, Watts D Heather, Gandhi Monica, Mocharnuk Robert S, Anastos Kathryn

机构信息

SUNY Downstate Medical Center, 450 Clarkson Ave, Brooklyn, NY 11203, USA.

出版信息

Am J Public Health. 2006 Jun;96(6):1060-5. doi: 10.2105/AJPH.2005.062745. Epub 2006 May 2.

DOI:10.2105/AJPH.2005.062745
PMID:16670229
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1470629/
Abstract

OBJECTIVE

We assessed the association of cigarette smoking with the effectiveness of highly active antiretroviral therapy (HAART) among low-income women.

METHODS

Data were analyzed from the Women's Interagency HIV Study, a multisite longitudinal study up to 7.9 years for 924 women representing 72% of all women who initiated HAART between July 1, 1995, and September 30, 2003.

RESULTS

When Cox's regression was used after control for age, race, hepatitis C infection, illicit drug use, previous antiretroviral therapy, and previous AIDS, smokers on HAART had poorer viral responses (hazard ratio [HR]=0.79; 95% confidence interval [CI]=0.67, 0.93) and poorer immunologic response (HR=0.85; 95% CI=0.73, 0.99). A greater risk of virologic rebound (HR=1.39; 95% CI=1.06, 1.69) and more frequent immunologic failure (HR=1.52; 95% CI=1.18, 1.96) were also observed among smokers. There was a higher risk of death (HR=1.53; 95% CI=1.08, 2.19) and a higher risk of developing AIDS (HR=1.36; 95% CI=1.07, 1.72) but no significant difference between smokers and nonsmokers in the risk of death due to AIDS.

CONCLUSIONS

Some of the benefits provided by HAART are negated in cigarette smokers.

摘要

目的

我们评估了低收入女性中吸烟与高效抗逆转录病毒疗法（HAART）疗效之间的关联。

方法

对妇女机构间HIV研究的数据进行了分析，这是一项多地点纵向研究，对924名女性进行了长达7.9年的跟踪，这些女性占1995年7月1日至2003年9月30日期间开始接受HAART治疗的所有女性的72%。

结果

在对年龄、种族、丙型肝炎感染、非法药物使用、既往抗逆转录病毒治疗和既往艾滋病进行控制后，使用Cox回归分析发现，接受HAART治疗的吸烟者病毒反应较差（风险比[HR]=0.79；95%置信区间[CI]=0.67，0.93），免疫反应也较差（HR=0.85；95%CI=0.73，0.99）。吸烟者中病毒学反弹的风险更高（HR=1.39；95%CI=1.06，1.69），免疫失败更频繁（HR=1.52；95%CI=1.18，1.96）。吸烟者死亡风险更高（HR=1.53；95%CI=1.08，2.19），患艾滋病的风险更高（HR=1.36；95%CI=1.07，1.72），但吸烟者和非吸烟者因艾滋病死亡的风险没有显著差异。

结论

HAART带来的一些益处在吸烟者中被抵消了。