Amar Jacques, Fauvel Josette, Drouet Ludovic, Ruidavets Jean Bernard, Perret Bertrand, Chamontin Bernard, Boccalon Henri, Ferrieres Jean
Service de Médecine Interne et d'Hypertension Artérielle, CHU Toulouse, IFR 126, France.
J Hypertens. 2006 Jun;24(6):1083-8. doi: 10.1097/01.hjh.0000226198.44181.0c.
Among the markers of inflammation, a cytokine, interleukin (IL)-6, promotes the expression of intercellular adhesion molecule 1 (ICAM-1), C-reactive protein (CRP) synthesis, and leads to a series of procoagulant actions with potential major implications on the progression of atherosclerosis.
To analyse in a population-based study, the relationship between IL-6 and atherosclerotic lesions and the role of serum ICAM-1 and CRP on this relationship.
Among 1015 individuals randomly recruited between 1995 and 1997 in Haute-Garonne, a French region with a low cardiovascular risk, 953 subjects with complete data for all measurements were analysed. Common carotid intima-media thickness (IMT) and the presence of plaques in the carotid and femoral arteries were assessed by ultrasonography.
Quartiles of IL-6, serum ICAM-1 and CRP were positively associated with plaques and IMT. After adjustment for traditional risk factors, IL-6 (P < 0.001) and serum ICAM-1 (P < 0.002) remained positively associated with plaques but not CRP (P = 0.20). Neither IL-6, nor serum ICAM-1, nor CRP were independently associated with IMT. When serum ICAM-1 was entered into the model in addition to traditional risk factors and IL-6, the percentage of variance in the number of plaques explained by the model did not increase significantly.
IL-6 levels are associated with subclinical atherosclerotic lesions independently of traditional risk factors; the influence of IL-6 on ICAM-1 secretion may play a role in this association. These results argue the interest of IL-6 in the stratification of cardiovascular risk.
在炎症标志物中，细胞因子白细胞介素（IL）-6可促进细胞间黏附分子1（ICAM-1）的表达、C反应蛋白（CRP）的合成，并引发一系列促凝血作用，这可能对动脉粥样硬化的进展产生重大影响。
在一项基于人群的研究中，分析IL-6与动脉粥样硬化病变之间的关系，以及血清ICAM-1和CRP在这种关系中所起的作用。
1995年至1997年期间在法国上加龙省随机招募了1015名个体，该地区心血管疾病风险较低。对其中953名所有测量数据完整的受试者进行了分析。通过超声检查评估颈总动脉内膜中层厚度（IMT）以及颈动脉和股动脉中斑块的存在情况。
IL-6、血清ICAM-1和CRP的四分位数与斑块和IMT呈正相关。在对传统危险因素进行校正后，IL-6（P<0.001）和血清ICAM-1（P<0.002）仍与斑块呈正相关，但CRP与斑块无相关性（P = 0.20）。IL-6、血清ICAM-1和CRP均与IMT无独立相关性。当在传统危险因素和IL-6之外，将血清ICAM-1纳入模型时，模型所解释的斑块数量方差百分比并未显著增加。
IL-6水平与亚临床动脉粥样硬化病变相关，且独立于传统危险因素；IL-6对ICAM-1分泌的影响可能在此关联中起作用。这些结果表明IL-6在心血管风险分层中具有重要意义。
