de Koning Dirk-Jan
Genetics and Genomics, The Roslin Institute, Roslin, Midlothian EH25 9PS, UK.
Trends Genet. 2006 Jun;22(6):301-5. doi: 10.1016/j.tig.2006.04.006. Epub 2006 May 11.
Genome scans have identified quantitative trait loci (QTLs) affecting milk yield and composition in dairy cattle. For one QTL on bovine chromosome 6 (BTA6), previously fine-mapped to a 420-Kb region, mutations in two different genes (OPN and ABCG2) have been proposed as the underlying functional mutation. Comparing the arguments for each gene suggests that both mutations are equally probable. However, functional studies and/or additional populations are required to provide a definite answer.
基因组扫描已鉴定出影响奶牛产奶量和乳成分的数量性状基因座（QTL）。对于牛6号染色体（BTA6）上的一个QTL，此前已精细定位到一个420千碱基对的区域，有人提出两个不同基因（OPN和ABCG2）中的突变是潜在的功能突变。比较支持每个基因的论据表明，这两种突变的可能性相同。然而，需要进行功能研究和/或研究更多群体才能给出明确答案。
