减毒温度敏感甲型流感病毒（H3N2）未能在人类中诱导对1型副流感病毒的异源干扰。
Failure of attenuated temperature-sensitive influenza A (H3N2) virus to induce heterologous interference in humans to parainfluenza type 1 virus.
作者信息
Murphy B R, Richman D D, Chalhub E G, Uhlendorf C P, Baron S, Chanock R M
出版信息
Infect Immun. 1975 Jul;12(1):62-8. doi: 10.1128/iai.12.1.62-68.1975.
Abstract
The present investigation was undertaken to determine if a candidate live vaccine virus, influenza A/Hong Kong/68-ts-1 [E] (H3N2), induced heterologous interference against an interferon-sensitive, wild-type, parainfluenza type 1 challenge virus. The parainfluenza virus was administered 7 days after Hong Kong/68-ts-1 [E] virus infection. The clinical response, daily quantitative virus shedding, interferon production, and serum and nasal wash antibody responses were determined in an experimental group (influenza A virus followed by parainfluenza virus) and 10 volunteers in a control group (parainfluenza virus only). The volunteers were selected on the basis of susceptibility to the two viruses, i.e. serum hemagglutination-inhibition antibody titer of is less than or greater to 1:8 for influenza virus and low nasal wash antibody titer (is less than or greater to 1:8) for parainfluenza virus. Despite a 100% infection rate in the Hong Kong/68-ts-1 [E] vaccinees, no heterologous interference was induced against the parainfluenza type 1 virus challenge.
摘要
本研究旨在确定候选活疫苗病毒甲型流感/香港/68-ts-1 [E]（H3N2）是否能诱导对干扰素敏感的野生型1型副流感攻击病毒产生异源干扰。在香港/68-ts-1 [E]病毒感染7天后接种副流感病毒。在一个实验组（先接种甲型流感病毒，后接种副流感病毒）和10名对照组志愿者（仅接种副流感病毒）中测定了临床反应、每日定量病毒排出量、干扰素产生以及血清和鼻腔冲洗液抗体反应。志愿者是根据对这两种病毒的易感性挑选的，即甲型流感病毒的血清血凝抑制抗体效价小于或大于1:8，1型副流感病毒的鼻腔冲洗液抗体效价低（小于或大于1:8）。尽管接种香港/68-ts-1 [E]疫苗的人感染率为100%，但未诱导出对1型副流感病毒攻击的异源干扰。
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本文引用的文献
1
Failure of naturally acquired rhinovirus infections to produce temporal immunity to heterologous serotypes.自然获得的鼻病毒感染未能产生对异源血清型的暂时免疫力。
Infect Immun. 1974 Nov;10(5):1192-3. doi: 10.1128/iai.10.5.1192-1193.1974.
2
The influence of certain salts, amino acids, sugars, and proteins on the stability of rickettsiae.某些盐类、氨基酸、糖类及蛋白质对立克次氏体稳定性的影响。
J Bacteriol. 1950 Apr;59(4):509-22. doi: 10.1128/jb.59.4.509-522.1950.
3
Interference phenomena between animal viruses; a review.动物病毒之间的干扰现象；综述
J Immunol. 1950 Mar;64(3):203-36.
4
THE USE OF VOLUNTEERS IN MEDICAL VIROLOGY.志愿者在医学病毒学中的应用。
Prog Med Virol. 1964;6:1-26.
5
STUDIES WITH RHINOVIRUSES IN VOLUNTEERS: PRODUCTION OF ILLNESS, EFFECT OF NATURALLLY ACQUIRED ANTIBODY, AND DEMONSTRATION OF A PROTECTIVE EFFECT NOT ASSOCIATED WITH SERUM ANTIBODY.志愿者鼻病毒研究：疾病的产生、自然获得抗体的影响以及与血清抗体无关的保护作用的证明
J Clin Invest. 1964 Jan;43(1):56-67. doi: 10.1172/JCI104894.
6
Infection of human volunteers with type 2 hemadsorption virus.2型血细胞吸附病毒对人类志愿者的感染。
Science. 1958 Oct 3;128(3327):779-80. doi: 10.1126/science.128.3327.779.
7
Interferon in mice: protection against small doses of virus.小鼠体内的干扰素：抵御小剂量病毒
J Gen Virol. 1967 Jul;1(3):395-7. doi: 10.1099/0022-1317-1-3-395.
8
A statewide mass measles immunization program.一项全州范围的大规模麻疹免疫计划。
JAMA. 1967 Feb 27;199(9):619-23.
9
Temperature-sensitive mutants of influenza virus. IV. Induction of interferon in the nasopharynx by wild-type and a temperature-sensitive recombinant virus.流感病毒的温度敏感突变体。IV. 野生型和温度敏感重组病毒在鼻咽部诱导干扰素的情况。
J Infect Dis. 1973 Oct;128(4):488-93. doi: 10.1093/infdis/128.4.488.
10
Temperature-sensitive mutants of influenza virus. 3. Further characterization of the ts-1(E) influenza A recombinant (H3N2) virus in man.流感病毒的温度敏感突变体。3. 甲型重组（H3N2）ts-1（E）流感病毒在人体中的进一步特性研究。
J Infect Dis. 1973 Oct;128(4):479-87. doi: 10.1093/infdis/128.4.479.
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