Murphy B R, Richman D D, Chalhub E G, Uhlendorf C P, Baron S, Chanock R M
Infect Immun. 1975 Jul;12(1):62-8. doi: 10.1128/iai.12.1.62-68.1975.
The present investigation was undertaken to determine if a candidate live vaccine virus, influenza A/Hong Kong/68-ts-1 [E] (H3N2), induced heterologous interference against an interferon-sensitive, wild-type, parainfluenza type 1 challenge virus. The parainfluenza virus was administered 7 days after Hong Kong/68-ts-1 [E] virus infection. The clinical response, daily quantitative virus shedding, interferon production, and serum and nasal wash antibody responses were determined in an experimental group (influenza A virus followed by parainfluenza virus) and 10 volunteers in a control group (parainfluenza virus only). The volunteers were selected on the basis of susceptibility to the two viruses, i.e. serum hemagglutination-inhibition antibody titer of is less than or greater to 1:8 for influenza virus and low nasal wash antibody titer (is less than or greater to 1:8) for parainfluenza virus. Despite a 100% infection rate in the Hong Kong/68-ts-1 [E] vaccinees, no heterologous interference was induced against the parainfluenza type 1 virus challenge.
本研究旨在确定候选活疫苗病毒甲型流感/香港/68-ts-1 [E]（H3N2）是否能诱导对干扰素敏感的野生型1型副流感攻击病毒产生异源干扰。在香港/68-ts-1 [E]病毒感染7天后接种副流感病毒。在一个实验组（先接种甲型流感病毒，后接种副流感病毒）和10名对照组志愿者（仅接种副流感病毒）中测定了临床反应、每日定量病毒排出量、干扰素产生以及血清和鼻腔冲洗液抗体反应。志愿者是根据对这两种病毒的易感性挑选的，即甲型流感病毒的血清血凝抑制抗体效价小于或大于1:8，1型副流感病毒的鼻腔冲洗液抗体效价低（小于或大于1:8）。尽管接种香港/68-ts-1 [E]疫苗的人感染率为100%，但未诱导出对1型副流感病毒攻击的异源干扰。
