食管鳞状细胞癌中无EB病毒。
Absence of Epstein-Barr virus in oesophageal squamous cell carcinoma.
作者信息
Lam K Y, Srivastava G, Leung M L, Ma L
机构信息
Department of Pathology, Queen Mary's Hospital, Hong Kong.
出版信息
Clin Mol Pathol. 1995 Aug;48(4):M188-90. doi: 10.1136/mp.48.4.m188.
Aim-To identify the possible role of Epstein-Barr virus (EBV), in Chinese patients, in the pathogenesis of oesophageal squamous cell carcinoma.Methods-Formalin fixed, paraffin wax embedded tissues from 74 cases of oesophageal squamous cell carcinoma (28 with well differentiated, 27 with moderately differentiated and 18 with poorly differentiated carcinomas) were analysed for EBV using in situ hybridisation for EBV encoded small RNAs.Results-EBV was detected in only a few lymphocytes adjacent to the tumour epithelia in 14 (19%) cases of oesophageal carcinoma. The adjacent, non-pathological oesophageal tissue was EBV negative.Conclusions-EBV does not play a major role in the aetiology of oesophageal squamous cell carcinoma.
目的——确定在中国患者中，爱泼斯坦-巴尔病毒（EBV）在食管鳞状细胞癌发病机制中可能发挥的作用。
方法——采用原位杂交检测EBV编码的小RNA，对74例食管鳞状细胞癌（28例高分化、27例中分化、18例低分化癌）的福尔马林固定、石蜡包埋组织进行EBV分析。
结果——14例（19%）食管癌病例中，仅在肿瘤上皮附近的少数淋巴细胞中检测到EBV。相邻的非病变食管组织EBV呈阴性。
结论——EBV在食管鳞状细胞癌的病因学中不发挥主要作用。
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