Tal A, Sanchez I, Pasterkamp H
Department of Pediatrics, Ben Gurion University, Beersheba, Israel.
Am J Dis Child. 1991 Dec;145(12):1405-10. doi: 10.1001/archpedi.1991.02160120073023.
Respirosonography was used to analyze lung sounds and breathing patterns in 16 infants with acute bronchiolitis who were treated with nebulized salbutamol (albuterol). Wheezing was measured as a proportion of respiratory time (time spent wheezing [Tw]/total time [Ttot]). A decrease of 10% or greater in Tw/Ttot or a reduction in Tw/Ttot to less than 2% was considered a positive response to salbutamol. Seven infants responded to the salbutamol, and nine did not. In responders, Tw/Ttot decreased from 47% +/- 26% to 20% +/- 25% (mean +/- SD), and the respiratory rate decreased from 65 +/- 8 to 57 +/- 7 breaths per minute. In nonresponders, mean Tw/Ttot either did not change or increased, and there was no significant change in respiratory rate (53 +/- 10 breaths per minute before salbutamol inhalation and 56 +/- 9 breaths per minute after salbutamol inhalation). Complex repetitive waveforms, different from the sinusoidal waveforms of typical wheezing, were observed in 14 of 16 infants. Our findings add supportive evidence to the clinical impression that some infants with bronchiolitis respond to salbutamol. Respirosonography provides a noninvasive method for objective clinical assessment of young, wheezy children.
采用呼吸声谱分析法对16例接受雾化沙丁胺醇（舒喘灵）治疗的急性细支气管炎婴儿的肺音和呼吸模式进行分析。哮鸣音以呼吸时间的比例来衡量（哮鸣音持续时间[Tw]/总时间[Ttot]）。Tw/Ttot降低10%或更多，或Tw/Ttot降至2%以下被认为是对沙丁胺醇的阳性反应。7例婴儿对沙丁胺醇有反应，9例无反应。有反应者中，Tw/Ttot从47%±26%降至20%±25%（平均值±标准差），呼吸频率从每分钟65±8次降至57±7次。无反应者中，Tw/Ttot平均值要么未改变要么升高，呼吸频率无显著变化（吸入沙丁胺醇前每分钟53±10次，吸入沙丁胺醇后每分钟56±9次）。在16例婴儿中的14例观察到了不同于典型哮鸣音正弦波形的复杂重复波形。我们的研究结果为一些细支气管炎婴儿对沙丁胺醇有反应这一临床印象提供了支持性证据。呼吸声谱分析为客观临床评估年幼的喘息儿童提供了一种非侵入性方法。
