Klassen T P, Rowe P C, Sutcliffe T, Ropp L J, McDowell I W, Li M M
Department of Pediatrics, University of Ottawa School of Medicine, Ontario, Canada.
J Pediatr. 1991 May;118(5):807-11. doi: 10.1016/s0022-3476(05)80051-4.
To test whether nebulized salbutamol (albuterol) is safe and efficacious for the treatment of young children with acute bronchiolitis, we enrolled 83 children (median age 6 months, range 1 to 21 months) in a randomized, double-blind clinical trial. Participants received two treatments at 30-minute intervals of either nebulized salbutamol (0.10 mg/kg in 2 ml 0.9% saline solution) or a similar volume of 0.9% saline solution placebo. Outcome measures were the respiratory rate, pulse oximetry, and a clinical score based on the degree of wheezing and retractions. Patients in the salbutamol arm had significantly greater improvement in clinical scores after the initial treatment (p = 0.04). There was no difference between the groups in oxygen saturation (p = 0.74); patients treated with salbutamol had a small increase in heart rate after two treatments (159 +/- 16 vs 151 +/- 16; p = 0.03). We conclude that salbutamol is safe and effective for the initial treatment of young children with acute bronchiolitis.
为了测试雾化沙丁胺醇（舒喘宁）治疗婴幼儿急性细支气管炎是否安全有效，我们开展了一项随机双盲临床试验，纳入了83名儿童（年龄中位数为6个月，范围为1至21个月）。参与者每隔30分钟接受两种治疗之一，即雾化沙丁胺醇（0.10mg/kg溶于2ml 0.9%盐溶液）或等量的0.9%盐溶液安慰剂。观察指标为呼吸频率、脉搏血氧饱和度以及基于喘息和呼吸凹陷程度的临床评分。沙丁胺醇组患者在初始治疗后临床评分有显著改善（p = 0.04）。两组的血氧饱和度无差异（p = 0.74）；接受沙丁胺醇治疗的患者在两次治疗后心率略有增加（159±16对151±16；p = 0.03）。我们得出结论，沙丁胺醇对婴幼儿急性细支气管炎初始治疗是安全有效的。
