Trebatická Jana, Kopasová Sona, Hradecná Zuzana, Cinovský Kamil, Skodácek Igor, Suba Ján, Muchová Jana, Zitnanová Ingrid, Waczulíková Iweta, Rohdewald Peter, Duracková Zdenka
Dept. of Child Psychiatry, Child University Hospital, Faculty of Medicine, Comenius University, Limbová 1, 833 40 Bratislava, Slovakia.
Eur Child Adolesc Psychiatry. 2006 Sep;15(6):329-35. doi: 10.1007/s00787-006-0538-3. Epub 2006 May 13.
Attention Deficit/Hyperactivity Disorder (ADHD) is the most common psychiatric disorder in children. Pycnogenol, an extract from the bark of the French maritime pine, consisting of phenolic acids, catechin, taxifolin and procyanidins, has shown improvement of ADHD in case reports and in an open study. Aim of the present study was to evaluate the effect of Pycnogenol on ADHD symptoms. Sixty-one children were supplemented with 1 mg/kg/day Pycnogenol or placebo over a period of 4 weeks in a randomised, placebo-controlled, doubleblind study. Patients were examined at start of trial, 1 month after treatment and 1 month after end of treatment period by standard questionnaires: CAP (Child Attention Problems) teacher rating scale, Conner's Teacher Rating Scale (CTRS), the Conner's Parent Rating Scale (CPRS) and a modified Wechsler Intelligence Scale for children. Results show that 1-month Pycnogenol administration caused a significant reduction of hyperactivity, improves attention and visual-motoric coordination and concentration of children with ADHD. In the placebo group no positive effects were found. One month after termination of Pycnogenol administration a relapse of symptoms was noted. Our results point to an option to use Pycnogenol as a natural supplement to relieve ADHD symptoms of children.
注意缺陷多动障碍（ADHD）是儿童中最常见的精神疾病。碧萝芷是一种从法国滨海松树皮中提取的物质，由酚酸、儿茶素、紫杉叶素和原花青素组成，在病例报告和一项开放性研究中显示对ADHD有改善作用。本研究的目的是评估碧萝芷对ADHD症状的影响。在一项随机、安慰剂对照、双盲研究中，61名儿童在4周时间内每天补充1mg/kg的碧萝芷或安慰剂。在试验开始时、治疗1个月后以及治疗期结束后1个月，通过标准问卷对患者进行检查：儿童注意力问题（CAP）教师评定量表、康纳教师评定量表（CTRS）、康纳家长评定量表（CPRS）以及儿童韦氏智力量表的修订版。结果显示，服用碧萝芷1个月可显著减少多动症状，改善ADHD儿童的注意力、视觉运动协调能力和注意力集中程度。在安慰剂组未发现积极效果。停止服用碧萝芷1个月后，症状出现复发。我们的结果表明，碧萝芷可作为一种天然补充剂用于缓解儿童的ADHD症状。
