Dvoráková Monika, Jezová Daniela, Blazícek Pavol, Trebatická Jana, Skodácek Igor, Suba Ján, Iveta Waczulíková, Rohdewald Peter, Duracková Zdenka
Department of Medical Chemistry, Biochemistry and Clinical Biochemistry, Faculty of Medicine, Comenius University, Bratislava, Slovak Republic.
Nutr Neurosci. 2007 Jun-Aug;10(3-4):151-7. doi: 10.1080/09513590701565443.
Our study tested the hypothesis that treatment with a potent polyphenol complex not only reduces hyperactivity of children, but also catecholamine excretion and oxidative stress. Urine catecholamine concentrations were measured in attention deficit hyperactivity disorder (ADHD) children and healthy controls. ADHD children received either placebo (PL) or Pycnogenol (Pyc), a bioflavonoid extract from the pine bark, for one month. The study was performed in a randomized, double-blind, PL controlled design. Concentrations of catecholamines were higher in urine of ADHD patients compared to those of healthy children. Moreover, noradrenaline (NA) concentrations positively correlated with degree of hyperactivity of ADHD children. In ADHD patients, adrenaline (A) and NA concentrations positively correlated with plasma levels of oxidized glutathione. The treatment of ADHD children with Pyc caused decrease of dopamine (D) and trend of A and NA decrase and increased GSH/GSSG ratio. In conclusion, the data provide further evidence for the overactivity of the noradrenergic system in ADHD and demonstrate that A release may be increased, as well. Treatment of ADHD children with Pyc normalized catecholamine concentrations, leading to less hyperactivity, and, consequently, to reduced oxidative stress.
我们的研究检验了这样一个假设，即使用一种强效多酚复合物进行治疗不仅可以降低儿童的多动症状，还能减少儿茶酚胺排泄及氧化应激。我们测量了注意力缺陷多动障碍（ADHD）儿童和健康对照者尿液中的儿茶酚胺浓度。ADHD儿童接受了为期一个月的安慰剂（PL）或碧萝芷（Pyc，一种从松树皮中提取的生物类黄酮提取物）治疗。该研究采用随机、双盲、PL对照设计。与健康儿童相比，ADHD患者尿液中的儿茶酚胺浓度更高。此外，可以观察到去甲肾上腺素（NA）浓度与ADHD儿童的多动程度呈正相关。在ADHD患者中，肾上腺素（A）和NA浓度与氧化型谷胱甘肽的血浆水平呈正相关。用Pyc治疗ADHD儿童会导致多巴胺（D）减少，A和NA有下降趋势，同时谷胱甘肽氧化还原电位（GSH/GSSG）比值增加。总之，这些数据为ADHD中去甲肾上腺素能系统的过度活跃提供了进一步的证据，并且表明A的释放也可能增加。用Pyc治疗ADHD儿童可使儿茶酚胺浓度正常化，从而减少多动症状，进而减轻氧化应激。
