Scott Elaine, Mawson Susan J
Muscular Dystrophy Campaign, London, UK.
Dev Med Child Neurol. 2006 Jun;48(6):540-4. doi: 10.1017/S0012162206001137.
A review of the measures relating to the monitoring of disease progression in Duchenne muscular dystrophy was undertaken as part of the work of the North Star Clinical Network for Paediatric Neuromuscular Disease Management developing a standardized assessment protocol for ambulant children in the UK. This article outlines the process of identifying possible measures. Detailed consideration has been given to key measures of muscle strength and function. As well as the usual assessment of the validity and reliability of the measures, three key characteristics were identified as necessary to the assessment of scales used in health care: (1) the type of scale used; (2) the clinical significance of the attribute being measured; and (3) the mathematical properties of the data provided. Consideration of such aspects in the early stage of a study facilitates the choice of measures, and the analysis and interpretation of data in the longer term.
作为北极星儿科神经肌肉疾病管理临床网络为英国能行走儿童制定标准化评估方案工作的一部分，对杜氏肌营养不良症疾病进展监测相关措施进行了综述。本文概述了确定可能措施的过程。已对肌肉力量和功能的关键措施进行了详细考虑。除了对这些措施的有效性和可靠性进行常规评估外，还确定了医疗保健中使用的量表评估所需的三个关键特征：(1) 所使用量表的类型；(2) 所测量属性的临床意义；(3) 所提供数据的数学特性。在研究早期考虑这些方面有助于措施的选择以及长期的数据分析和解释。
