Rodarte C, Hood D C, Yang E B, Grippo T, Greenstein V C, Liebmann J M, Ritch R
Department of Psychology, 405 Schermerhorn, Columbia University, New York, NY 10027, USA.
Br J Ophthalmol. 2006 Sep;90(9):1132-6. doi: 10.1136/bjo.2006.095158. Epub 2006 May 17.
To determine the effect of glaucomatous damage on the latency of the multifocal visual evoked potential (mfVEP).
Monocular mfVEPs were recorded from a glaucoma group (n = 50) defined by a glaucomatous disc and an abnormal visual field and a control group (n = 47). 25 patients were characterised as normal tension glaucoma (NTG) and 25 as high tension glaucoma (HTG). Monocular and interocular latency analyses of the more affected eye were obtained using custom software.
On interocular analysis, both the HTG and NTG groups showed a statistically significant increase in mean mfVEP latency with average relative latencies and percentage of points with significant delays of 1.7 ms and 10.3% (HTG) and 1.3 ms and 8.2% (NTG) compared to -0.3 ms and 2.7% (controls). On monocular analysis, only the HTG group showed a significant increase in latency with measures of 5.7 ms and 14.6% (HTG) compared to 3.2 ms and 10.6% (NTG) and 2.1 ms and 9.6% (controls). Using the 95th percentile of a normative group as the cut off, the sensitivity ranged from 20% to 38% and the specificity from 87% to 100% with the interocular analysis providing the best discrimination,
Although up to 40% of patients showed delays in the mfVEP latency, these delays were modest, on average a few milliseconds. These results differ markedly from those of a recent conventional VEP study, which reported 100% sensitivity, 100% specificity, and an average delay that exceeded 25 ms.
确定青光眼性损害对多焦视觉诱发电位（mfVEP）潜伏期的影响。
从由青光眼性视盘和异常视野定义的青光眼组（n = 50）和对照组（n = 47）记录单眼mfVEP。25例患者被归类为正常眼压性青光眼（NTG），25例为高眼压性青光眼（HTG）。使用定制软件对受影响更严重的眼睛进行单眼和双眼潜伏期分析。
在双眼分析中，与对照组的-0.3 ms和2.7%相比，HTG组和NTG组的mfVEP平均潜伏期均有统计学显著增加，平均相对潜伏期和显著延迟点的百分比分别为1.7 ms和10.3%（HTG）以及1.3 ms和8.2%（NTG）。在单眼分析中，只有HTG组的潜伏期有显著增加，测量值为5.7 ms和14.6%（HTG），而NTG组为3.2 ms和10.6%，对照组为2.1 ms和9.6%。以正常组的第95百分位数作为临界值，双眼分析的敏感性范围为20%至38%，特异性范围为87%至100%，双眼分析提供了最佳的区分度。
尽管高达40%的患者mfVEP潜伏期出现延迟，但这些延迟程度较轻，平均只有几毫秒。这些结果与最近一项传统VEP研究的结果明显不同，该研究报告的敏感性为100%，特异性为100%，平均延迟超过25 ms。
