Verschooten Lien, Claerhout Sofie, Van Laethem An, Agostinis Patricia, Garmyn Marjan
Department of Dermatology, Catholic University of Leuven, Belgium.
Photochem Photobiol. 2006 Jul-Aug;82(4):1016-23. doi: 10.1562/2006-04-27-ir-884.1.
Adequate photoprotection is essential to control UV-related disorders, including sunburn, photoaging and photocarcinogenisis. Sun avoidance, protection of skin with clothing, and sunscreens are presently the best way of photoprotection, assuming that they are used properly. However, new strategies, which are based on or make use of the endogenous protective response to UV light, may further improve currently used photoprotective means. The addition of repair enzymes and/or antioxidants has a positive effect on skin's recovery from UV-induced DNA-damage. Several botanical agents, mainly vitamins and polyphenols, have shown to influence signal transduction pathways leading to photoprotective effects. Also stimulation of endogenous UV-response pathways via irradiation with a low UV dose or via simulation of UV-induced DNA-damage results in photoprotective effects. Future research in this field and combination of different photoprotective strategies will hopefully lead to improved photoprotection.
充分的光防护对于控制与紫外线相关的疾病至关重要，这些疾病包括晒伤、光老化和光致癌作用。避免日晒、用衣物保护皮肤以及使用防晒霜目前是光防护的最佳方法，前提是正确使用。然而，基于内源性紫外线防护反应或利用该反应的新策略可能会进一步改善目前使用的光防护手段。添加修复酶和/或抗氧化剂对皮肤从紫外线诱导的DNA损伤中恢复有积极作用。几种植物制剂，主要是维生素和多酚，已显示出会影响导致光防护作用的信号转导途径。此外，通过低剂量紫外线照射或模拟紫外线诱导的DNA损伤来刺激内源性紫外线反应途径也会产生光防护作用。该领域的未来研究以及不同光防护策略的结合有望带来更好的光防护效果。
