McKeigue P M, Shah B, Marmot M G
Department of Community Medicine, University College and Middlesex School of Medicine, London, UK.
Lancet. 1991 Feb 16;337(8738):382-6. doi: 10.1016/0140-6736(91)91164-p.
The hypothesis that the high mortality from coronary heart disease (CHD) in South Asians settled overseas compared with other populations is due to metabolic disturbances related to insulin resistance was tested in a population survey of 3193 men and 561 women aged 40-69 years in London, UK. The sample was assembled from industrial workforces and general practitioners' lists. In comparison with the European group, the South Asian group had a higher prevalence of diabetes (19% vs 4%), higher blood pressures, higher fasting and post-glucose serum insulin concentrations, higher plasma triglyceride, and lower HDL cholesterol concentrations. Mean waist-hip girth ratios and trunk skinfolds were higher in the South Asian than in the European group. Within each ethnic group waist-hip ratio was correlated with glucose intolerance, insulin, blood pressure, and triglyceride. These results confirm the existence of an insulin resistance syndrome, prevalent in South Asian populations and associated with a pronounced tendency to central obesity in this group. Control of obesity and greater physical activity offer the best chances for prevention of diabetes and CHD in South Asian people.
在英国伦敦对3193名40至69岁男性和561名40至69岁女性进行的一项人口调查中，检验了这样一个假设：与其他人群相比，海外定居的南亚人冠心病（CHD）死亡率较高是由于与胰岛素抵抗相关的代谢紊乱所致。该样本是从产业工人和全科医生名单中选取的。与欧洲组相比，南亚组糖尿病患病率更高（19%对4%）、血压更高、空腹和葡萄糖负荷后血清胰岛素浓度更高、血浆甘油三酯更高以及高密度脂蛋白胆固醇浓度更低。南亚组的平均腰臀围比和躯干皮褶厚度高于欧洲组。在每个种族群体中，腰臀比与葡萄糖耐量异常、胰岛素、血压和甘油三酯相关。这些结果证实了胰岛素抵抗综合征的存在，该综合征在南亚人群中普遍存在，并且与该群体明显的中心性肥胖倾向相关。控制肥胖和增加体力活动为预防南亚人群的糖尿病和冠心病提供了最佳机会。
