5-氨基-2,5-二脱氧-5-碘尿苷对单纯疱疹病毒的选择性抑制作用
Selective inhibition of herpes simplex virus by 5-amino-2,5-dideoxy-5-iodouridine.
作者信息
Cheng Y C, Goz B, Neenan J P, Ward D C, Prusoff W H
出版信息
J Virol. 1975 May;15(5):1284-5. doi: 10.1128/JVI.15.5.1284-1285.1975.
Abstract
5-Amino-2,5-dideoxy-5-iodouridine, a nel thymidine analogue, is a potent inhibitor of herpes simplex virus type 1 replication. In contrast to most other nucleoside analogues which possess antiviral activity, 5-amino-2,5-dideoxy-5-iodouridine exhibits little, if any, cellular toxicity. Preliminary evidence suggests that 5-amino-2,5-dideoxy-5-iodouridine selectively inhibits viral-specific DNA synthesis.
摘要
5-氨基-2,5-二脱氧-5-碘尿苷是一种胸苷类似物，是单纯疱疹病毒1型复制的有效抑制剂。与大多数具有抗病毒活性的其他核苷类似物不同，5-氨基-2,5-二脱氧-5-碘尿苷几乎没有细胞毒性（如果有也微乎其微）。初步证据表明，5-氨基-2,5-二脱氧-5-碘尿苷能选择性抑制病毒特异性DNA合成。
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2
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Annu Rev Pharmacol. 1970;10:143-70. doi: 10.1146/annurev.pa.10.040170.001043.
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