Haynes Barton F, Moody M Anthony, Verkoczy Laurent, Kelsoe Garnett, Alam S Munir
Duke Human Vaccine Institute, Duke University School of Medicine, Durham NC 27710, USA.
Hum Antibodies. 2005;14(3-4):59-67.
HIV-1 has evolved many ways to evade protective host immune responses, thus creating a number of problems for HIV vaccine developers. In particular, durable, broadly specific neutralizing antibodies to HIV-1 have proved difficult to induce with current HIV-1 vaccine candidates. The recent observation that some broadly neutralizing anti-HIV-1 envelope monoclonal antibodies have polyspecific reactivities to host antigens have raised the hypothesis that one reason antibodies against some of the conserved HIV-1 envelope trimer neutralizing epitopes are not routinely made may be down-regulation of some specificities of anti-HIV-1 antibody producing B cells by host B cell tolerance mechanisms.
HIV-1已经进化出多种方式来逃避宿主的保护性免疫反应，从而给HIV疫苗开发者带来了诸多问题。特别是，目前的HIV-1候选疫苗难以诱导产生持久、广泛特异性的HIV-1中和抗体。最近的观察发现，一些广泛中和的抗HIV-1包膜单克隆抗体对宿主抗原有多特异性反应，这引发了一种假说，即针对某些保守的HIV-1包膜三聚体中和表位的抗体不能常规产生的一个原因可能是宿主B细胞耐受机制下调了产生抗HIV-1抗体的B细胞的某些特异性。
