一株对特比萘芬耐药的新型临床红色毛癣菌分离株的生物学、生物化学及分子特征分析
Biological, biochemical, and molecular characterization of a new clinical Trichophyton rubrum isolate resistant to terbinafine.
作者信息
Osborne Colin S, Leitner Ingrid, Hofbauer Bettina, Fielding Ceri A, Favre Bertrand, Ryder Neil S
机构信息
Infectious Diseases, Novartis Institutes for BioMedical Research, Inc., Cambridge, MA 02139, USA.
出版信息
Antimicrob Agents Chemother. 2006 Jun;50(6):2234-6. doi: 10.1128/AAC.01600-05.
Abstract
We have characterized a new clinical strain of Trichophyton rubrum highly resistant to terbinafine but exhibiting normal susceptibility to drugs with other mechanisms of action. Resistance to terbinafine in this strain is caused by a missense mutation in the squalene epoxidase gene leading to the amino acid substitution F397L.
摘要
我们已鉴定出一株新型红色毛癣菌临床菌株，该菌株对特比萘芬具有高度抗性，但对具有其他作用机制的药物表现出正常敏感性。该菌株对特比萘芬的抗性是由角鲨烯环氧酶基因中的一个错义突变引起的，该突变导致氨基酸取代F397L。
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