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本文引用的文献

1

Amino acid substitution in Trichophyton rubrum squalene epoxidase associated with resistance to terbinafine.红色毛癣菌角鲨烯环氧酶中的氨基酸替代与对特比萘芬的耐药性相关。

Antimicrob Agents Chemother. 2005 Jul;49(7):2840-4. doi: 10.1128/AAC.49.7.2840-2844.2005.

2

Biochemical characterization of terbinafine-resistant Trichophyton rubrum isolates.特比萘芬耐药红色毛癣菌分离株的生化特性

Med Mycol. 2004 Dec;42(6):525-9. doi: 10.1080/13693780410001661482.

3

In vitro evolution of itraconazole resistance in Aspergillus fumigatus involves multiple mechanisms of resistance.烟曲霉中伊曲康唑耐药性的体外进化涉及多种耐药机制。

Antimicrob Agents Chemother. 2004 Nov;48(11):4405-13. doi: 10.1128/AAC.48.11.4405-4413.2004.

4

Evaluation of in vitro resistance in patients with onychomycosis who fail antifungal therapy.对抗真菌治疗失败的甲癣患者进行体外耐药性评估。

Dermatology. 2003;207(4):375-80. doi: 10.1159/000074118.

5

Molecular mechanism of terbinafine resistance in Saccharomyces cerevisiae.酿酒酵母中特比萘芬耐药性的分子机制。

Antimicrob Agents Chemother. 2003 Dec;47(12):3890-900. doi: 10.1128/AAC.47.12.3890-3900.2003.

6

In vitro analysis of the ability of Trichophyton rubrum to become resistant to terbinafine.红色毛癣菌对特比萘芬产生耐药性能力的体外分析。

Antimicrob Agents Chemother. 2003 Nov;47(11):3634-6. doi: 10.1128/AAC.47.11.3634-3636.2003.

7

In vitro susceptibility testing of ciclopirox, terbinafine, ketoconazole and itraconazole against dermatophytes and nondermatophytes, and in vitro evaluation of combination antifungal activity.环吡酮、特比萘芬、酮康唑和伊曲康唑对皮肤癣菌和非皮肤癣菌的体外药敏试验以及联合抗真菌活性的体外评估。

Br J Dermatol. 2003 Aug;149(2):296-305. doi: 10.1046/j.1365-2133.2003.05418.x.

8

Multiple sequence alignment with the Clustal series of programs.使用Clustal系列程序进行多序列比对。

Nucleic Acids Res. 2003 Jul 1;31(13):3497-500. doi: 10.1093/nar/gkg500.

9

Antifungal drug resistance.抗真菌药物耐药性

Clin Infect Dis. 2003 Jan 15;36(Suppl 1):S31-41. doi: 10.1086/344658.

10

Clinical Trichophyton rubrum strain exhibiting primary resistance to terbinafine.临床红色毛癣菌菌株对特比萘芬表现出原发性耐药。

Antimicrob Agents Chemother. 2003 Jan;47(1):82-6. doi: 10.1128/AAC.47.1.82-86.2003.

一株对特比萘芬耐药的新型临床红色毛癣菌分离株的生物学、生物化学及分子特征分析

Biological, biochemical, and molecular characterization of a new clinical Trichophyton rubrum isolate resistant to terbinafine.

作者信息

Osborne Colin S, Leitner Ingrid, Hofbauer Bettina, Fielding Ceri A, Favre Bertrand, Ryder Neil S

机构信息

Infectious Diseases, Novartis Institutes for BioMedical Research, Inc., Cambridge, MA 02139, USA.

出版信息

Antimicrob Agents Chemother. 2006 Jun;50(6):2234-6. doi: 10.1128/AAC.01600-05.

DOI:10.1128/AAC.01600-05

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1479141/

Abstract

We have characterized a new clinical strain of Trichophyton rubrum highly resistant to terbinafine but exhibiting normal susceptibility to drugs with other mechanisms of action. Resistance to terbinafine in this strain is caused by a missense mutation in the squalene epoxidase gene leading to the amino acid substitution F397L.

摘要

我们已鉴定出一株新型红色毛癣菌临床菌株，该菌株对特比萘芬具有高度抗性，但对具有其他作用机制的药物表现出正常敏感性。该菌株对特比萘芬的抗性是由角鲨烯环氧酶基因中的一个错义突变引起的，该突变导致氨基酸取代F397L。