Edwards Paul C, Mason James M
Creighton University School of Dentistry, Omaha, NE, USA.
Head Face Med. 2006 May 25;2:16. doi: 10.1186/1746-160X-2-16.
Potential applications for gene-based tissue engineering therapies in the oral and maxillofacial complex include the delivery of growth factors for periodontal regeneration, pulp capping/dentin regeneration, and bone grafting of large osseous defects in dental and craniofacial reconstruction. Part 1 reviewed the principals of gene-enhanced tissue engineering and the techniques of introducing DNA into cells. This manuscript will review recent advances in gene-based therapies for dental hard tissue regeneration, specifically as it pertains to dentin regeneration/pulp capping and periodontal regeneration.
基于基因的组织工程疗法在口腔颌面部复合体中的潜在应用包括用于牙周再生、牙髓盖髓/牙本质再生以及牙体和颅面重建中大型骨缺损骨移植的生长因子递送。第1部分回顾了基因增强组织工程的原理以及将DNA导入细胞的技术。本手稿将回顾基于基因的牙硬组织再生疗法的最新进展，特别是与牙本质再生/牙髓盖髓和牙周再生相关的进展。
