Rashba Eric J, Shorofsky Stephen R, Scheiner Avram, Peters Robert W, Ma Carol, Gold Michael R
Division of Cardiology, University of Maryland School of Medicine, Baltimore, 21201, USA.
Heart Rhythm. 2006 Jun;3(6):647-52. doi: 10.1016/j.hrthm.2006.02.1029. Epub 2006 Mar 3.
Atrial defibrillation can be achieved with a conventional dual-coil, active pectoral implantable cardioverter-defibrillator (ICD) lead system. Shocking vectors that incorporate an additional electrode in the CS have been used, but it is unclear if they improve atrial DFTs.
The objective of this prospective, randomized study was to determine if a coronary sinus (CS) electrode reduces atrial defibrillation thresholds (DFTs).
This was a prospective study of 36 patients undergoing initial ICD implant for standard indications. A defibrillation lead with superior vena cava (SVC) and right ventricular (RV) shocking coils was implanted in the RV. An active can emulator (Can) was placed in a pre-pectoral pocket. A lead with a 4 cm long shocking coil was placed in the CS. Atrial DFTs were determined in the following 3 shocking configurations in each patient, with the order of testing randomized: RV --> SVC + Can (Ventricular Triad), distal CS --> SVC + Can (Distal Atrial Triad), and proximal CS --> SVC + Can (Proximal Atrial Triad).
The Proximal and Distal Atrial Triad configurations were both associated with significant reductions in peak current (p < 0.01), but this effect was offset by significant increases in shock impedance (p < 0.01), resulting in no net change in the peak voltage or DFT energy in comparison to the Ventricular Triad configuration (Ventricular Triad: 4.9 +/- 6.6 J, Proximal Atrial Triad: 3.3 +/- 4.1J, Distal Atrial Triad: 4.4 +/- 6.7 J, p > 0.2).
Shocking vectors that incorporate a CS coil do not significantly improve atrial defibrillation efficacy. Since the Ventricular Triad shocking pathway provides reliable atrial and ventricular defibrillation, this configuration should be preferred for combined atrial and ventricular ICDs.
使用传统的双线圈、主动胸壁植入式心脏复律除颤器(ICD)导联系统可实现心房除颤。已使用在冠状窦(CS)中包含额外电极的电击向量,但尚不清楚它们是否能改善心房除颤阈值(DFT)。
这项前瞻性随机研究的目的是确定冠状窦(CS)电极是否能降低心房除颤阈值(DFT)。
这是一项对36例因标准适应证接受初次ICD植入的患者进行的前瞻性研究。将带有上腔静脉(SVC)和右心室(RV)电击线圈的除颤导联植入右心室。将一个主动式模拟罐(Can)置于胸壁前口袋中。将一个带有4厘米长电击线圈的导联置于冠状窦中。在每位患者中,按随机顺序在以下3种电击配置下测定心房DFT:右心室→上腔静脉+模拟罐(心室三联律)、冠状窦远端→上腔静脉+模拟罐(远端心房三联律)、冠状窦近端→上腔静脉+模拟罐(近端心房三联律)。
近端和远端心房三联律配置均与峰值电流显著降低相关(p<0.01),但这种效应被电击阻抗的显著增加所抵消(p<0.01),与心室三联律配置相比,峰值电压或DFT能量无净变化(心室三联律:4.9±6.6焦耳,近端心房三联律:3.3±4.1焦耳,远端心房三联律:4.4±6.7焦耳,p>0.2)。
包含冠状窦线圈的电击向量不能显著提高心房除颤疗效。由于心室三联律电击途径可提供可靠的心房和心室除颤,对于兼具心房和心室功能的心内除颤器,应首选这种配置。