慢性溃疡性结肠炎中的核周抗中性粒细胞胞浆抗体（p-anca）：墨西哥一家机构的经验。
Perinuclear anti-neutrophil cytoplasmic antibodies (p-anca) in chronic ulcerative colitis: experience in a Mexican institution.
作者信息
Yamamoto-Furusho Jesus K, Takahashi-Monroy Takeshi, Vergara-Fernandez Omar, Reyes Edgardo, Uscanga Luis
机构信息
Department of Gastroenterology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico.
出版信息
World J Gastroenterol. 2006 Jun 7;12(21):3406-9. doi: 10.3748/wjg.v12.i21.3406.
AIM
To assess the prevalence and clinical value of p-ANCA in a sample of Mexican ulcerative colitis (UC) patients.
METHODS
In a prospective, IRB-approved protocol, p-ANCA was determined in 80 patients with UC (mean age, 32 +/- 12.9 years). The severity and extension of disease were determined by clinical methods, searching a statistical association with p-ANCA status.
RESULTS
p-ANCA were detected in 41 (51%) patients. Severity of disease was the only clinical variable statistically associated with their presence (P < 0.0001; OR = 9; CI 95% = 3.2-24.7).
CONCLUSION
The prevalence of p-ANCA was similar to that reported in other countries. Their presence was associated to UC severity, but offered no more information than the obtained by clinical methods.
目的
评估抗中性粒细胞胞浆抗体（p-ANCA）在一组墨西哥溃疡性结肠炎（UC）患者中的患病率及临床价值。
方法
在一项经机构审查委员会（IRB）批准的前瞻性研究方案中，对80例UC患者（平均年龄32±12.9岁）检测p-ANCA。通过临床方法确定疾病的严重程度和范围，并寻找与p-ANCA状态的统计学关联。
结果
41例（51%）患者检测到p-ANCA。疾病严重程度是唯一与p-ANCA存在具有统计学关联的临床变量（P<0.0001；比值比[OR]=9；95%置信区间[CI]=3.2-24.7）。
结论
p-ANCA的患病率与其他国家报道的相似。其存在与UC严重程度相关，但并未提供比临床方法更多的信息。
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