Friedman Michael, Vidyasagar Ramakrishnan, Joseph Ninos
Department of Otolaryngology and Bronchoesophagology, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois 60602, USA.
Laryngoscope. 2006 Jun;116(6):878-82. doi: 10.1097/01.mlg.0000216798.10007.76.
The objective of this randomized, prospective, double-blind study was to compare nasal irrigation using hypertonic Dead Sea salt (DSS) solution with hypertonic saline in the treatment of chronic rhinosinusitis and improvement of quality of life (QOL).
With Institutional Review Board approval, 42 adults seeking treatment for chronic rhinosinusitis in a tertiary university-affiliated medical center were studied. After history and endonasal examination, computed tomography imaging, and QOL survey (Standardized Rhinoconjunctivitis Quality of Life Questionnaire [RQLQ(S)]), patients were randomized to self-administered hypertonic saline spray and irrigation twice daily or hypertonic DSS spray and irrigation. Patients were reassessed weekly and at 1 month.
Both groups had similar symptoms and RQLQ(S) scores before treatment and had significant improvement after treatment. However, the DSS patients had significantly better symptom relief and only the DSS group showed improved RQLQ(S) scores.
We present a short-term study providing level I evidence on the superiority of DSS over saline nasal irrigation for treatment of chronic rhinosinusitis.
本随机、前瞻性、双盲研究的目的是比较使用高渗死海盐（DSS）溶液进行鼻腔冲洗与高渗盐水治疗慢性鼻窦炎及改善生活质量（QOL）的效果。
经机构审查委员会批准，对一所大学附属三级医疗中心的42名寻求慢性鼻窦炎治疗的成年人进行了研究。在进行病史采集、鼻内镜检查、计算机断层扫描成像和生活质量调查（标准化鼻结膜炎生活质量问卷 [RQLQ(S)]）后，患者被随机分为两组，分别每日两次自行使用高渗盐水喷雾和冲洗，或高渗DSS喷雾和冲洗。每周和1个月时对患者进行重新评估。
两组在治疗前症状和RQLQ(S)评分相似，治疗后均有显著改善。然而，DSS组患者的症状缓解明显更好，且只有DSS组的RQLQ(S)评分有所提高。
我们进行了一项短期研究，提供了一级证据，证明在治疗慢性鼻窦炎方面，DSS优于盐水鼻腔冲洗。
