Aya T, Kinoshita T, Imai S, Koizumi S, Mizuno F, Osato T, Satoh C, Oikawa T, Kuzumaki N, Ohigashi H
Department of Virology, Hokkaido University School of Medicine, Sapporo, Japan.
Lancet. 1991 May 18;337(8751):1190. doi: 10.1016/0140-6736(91)92861-u.
Dual exposure to Epstein-Barr virus and purified 4-deoxyphorbol ester derived from the plant Euphorbia tirucalli induced a high frequency of chromosomal rearrangements in human B lymphocytes in vitro. Rearrangements most commonly affected chromosome 8, the chromosome most often showing structural changes in Burkitt's lymphoma (BL) cells. E tirucalli is indigenous in parts of Africa where BL is endemic and may be an important risk factor for the disease.
在体外，爱泼斯坦-巴尔病毒（Epstein-Barr virus）与源自植物大戟（Euphorbia tirucalli）的纯化4-脱氧佛波酯双重暴露可诱导人B淋巴细胞发生高频染色体重排。重排最常影响8号染色体，该染色体在伯基特淋巴瘤（BL）细胞中最常出现结构变化。大戟在非洲部分地区为本土植物，而BL在这些地区呈地方性流行，大戟可能是该疾病的一个重要危险因素。
