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通过原位杂交将成纤维细胞生长因子受体基因定位到人类染色体10q26带。

Assignment by in situ hybridization of a fibroblast growth factor receptor gene to human chromosome band 10q26.

作者信息

Mattei M G, Moreau A, Gesnel M C, Houssaint E, Breathnach R

机构信息

INSERM Unité 242, Hôpital d'Enfants, Groupe Hospitalier de la Timone,Marseille, France.

出版信息

Hum Genet. 1991 May;87(1):84-6. doi: 10.1007/BF01213098.

Abstract

A 2.3-kb cDNA probe for the human bek fibroblast growth factor receptor was used to determine the chromosomal localization of the corresponding gene by in situ hybridization. The results show that this gene, a form of which is amplified in some poorly differentiated stomach cancers, is localized on chromosome region 10q26. The two previously identified fibroblast growth factor receptor genes are thus not on the same chromosome, as the related flg ("fms-like gene") fibroblast growth factor receptor gene has previously been mapped to human chromosome region 8p12.

摘要

利用针对人bek成纤维细胞生长因子受体的2.3kb cDNA探针,通过原位杂交来确定相应基因的染色体定位。结果显示,该基因(其一种形式在一些低分化胃癌中发生扩增)定位于染色体区域10q26。因此,先前鉴定的两个成纤维细胞生长因子受体基因并不在同一条染色体上,因为相关的flg(“fms样基因”)成纤维细胞生长因子受体基因先前已被定位到人类染色体区域8p12。

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