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通过原位杂交将成纤维细胞生长因子受体基因定位到人类染色体10q26带。

Assignment by in situ hybridization of a fibroblast growth factor receptor gene to human chromosome band 10q26.

作者信息

Mattei M G, Moreau A, Gesnel M C, Houssaint E, Breathnach R

机构信息

INSERM Unité 242, Hôpital d'Enfants, Groupe Hospitalier de la Timone,Marseille, France.

出版信息

Hum Genet. 1991 May;87(1):84-6. doi: 10.1007/BF01213098.

DOI:10.1007/BF01213098
PMID:1674718
Abstract

A 2.3-kb cDNA probe for the human bek fibroblast growth factor receptor was used to determine the chromosomal localization of the corresponding gene by in situ hybridization. The results show that this gene, a form of which is amplified in some poorly differentiated stomach cancers, is localized on chromosome region 10q26. The two previously identified fibroblast growth factor receptor genes are thus not on the same chromosome, as the related flg ("fms-like gene") fibroblast growth factor receptor gene has previously been mapped to human chromosome region 8p12.

摘要

利用针对人bek成纤维细胞生长因子受体的2.3kb cDNA探针，通过原位杂交来确定相应基因的染色体定位。结果显示，该基因（其一种形式在一些低分化胃癌中发生扩增）定位于染色体区域10q26。因此，先前鉴定的两个成纤维细胞生长因子受体基因并不在同一条染色体上，因为相关的flg（“fms样基因”）成纤维细胞生长因子受体基因先前已被定位到人类染色体区域8p12。

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Hum Genet. 1991 May;87(1):84-6. doi: 10.1007/BF01213098.
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本文引用的文献

1
Carrier detection of Hemophilia B by using a restriction site polymorphism associated with the coagulation Factor IX gene.利用与凝血因子IX基因相关的限制性酶切位点多态性进行B型血友病的携带者检测。
J Clin Invest. 1984 May;73(5):1491-5. doi: 10.1172/JCI111354.
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DNA probe localization at 18p113 band by in situ hybridization and identification of a small supernumerary chromosome.通过原位杂交将DNA探针定位在18p11.3带，并鉴定出一条小的额外染色体。
Hum Genet. 1985;69(3):268-71. doi: 10.1007/BF00293038.
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Chromosomal locations of human tissue plasminogen activator and urokinase genes.
人类FGFR4基因的基因组结构与完整序列
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Differential expression of two fibroblast growth factor-receptor genes is associated with malignant progression in human astrocytomas.两种成纤维细胞生长因子受体基因的差异表达与人类星形细胞瘤的恶性进展相关。
Proc Natl Acad Sci U S A. 1994 Jan 18;91(2):484-8. doi: 10.1073/pnas.91.2.484.
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Basic fibroblast growth factor and fibroblast growth factor receptor I are implicated in the growth of human astrocytomas.碱性成纤维细胞生长因子和成纤维细胞生长因子受体I与人类星形细胞瘤的生长有关。
J Neurooncol. 1994;18(3):207-16. doi: 10.1007/BF01328955.
Science. 1985 Nov 8;230(4726):672-4. doi: 10.1126/science.3840278.
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A new translocation, t(10;14)(q24;q11), in T cell neoplasia.T细胞肿瘤中一种新的易位，t(10;14)(q24;q11) 。
Blood. 1986 Apr;67(4):1181-4.
5
Basic fibroblast growth factor fused to a signal peptide transforms cells.与信号肽融合的碱性成纤维细胞生长因子可转化细胞。
Nature. 1988 Jan 14;331(6152):173-5. doi: 10.1038/331173a0.
6
An oncogene isolated by transfection of Kaposi's sarcoma DNA encodes a growth factor that is a member of the FGF family.通过转染卡波西肉瘤DNA分离出的一种癌基因编码一种生长因子，该生长因子是成纤维细胞生长因子（FGF）家族的成员。
Cell. 1987 Aug 28;50(5):729-37. doi: 10.1016/0092-8674(87)90331-x.
7
Dra I identifies a two allele DNA polymorphism in the human alpha 2-adrenergic receptor gene (ADRAR), using a 5.5 kb probe (p ADRAR).Dra I利用一个5.5 kb的探针（p ADRAR）鉴定出人类α2-肾上腺素能受体基因（ADRAR）中的一种双等位基因DNA多态性。
Nucleic Acids Res. 1988 Sep 26;16(18):9070. doi: 10.1093/nar/16.18.9070.
8
Cloning, sequencing, and expression of the gene coding for the human platelet alpha 2-adrenergic receptor.人血小板α2 - 肾上腺素能受体编码基因的克隆、测序及表达
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9
Receptor for acidic fibroblast growth factor is related to the tyrosine kinase encoded by the fms-like gene (FLG).酸性成纤维细胞生长因子受体与fms样基因（FLG）编码的酪氨酸激酶相关。
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