Amano Shiro, Honda Norihiko, Amano Yuki, Yamagami Satoru, Miyai Takashi, Samejima Tomokazu, Ogata Miyuki, Miyata Kazunori
Department of Ophthalmology, University of Tokyo School of Medicine, Tokyo, Japan.
Ophthalmology. 2006 Jun;113(6):937-41. doi: 10.1016/j.ophtha.2006.01.063.
To compare central corneal thickness measurements and their reproducibility when taken by a rotating Scheimpflug camera, ultrasonic pachymetry, and scanning-slit corneal topography/pachymetry.
Experimental study.
Seventy-four eyes of 64 subjects without ocular abnormalities other than cataract.
Corneal thickness measurements were compared among the 3 methods in 54 eyes of 54 subjects. Two sets of measurements were repeated by a single examiner for each pachymetry in another 10 eyes of 5 subjects, and the intraexaminer repeatability was assessed as the absolute difference of the first and second measurements. Two experienced examiners took one measurement for each pachymetry in another 10 eyes of 5 subjects, and the interexaminer reproducibility was assessed as the absolute difference of the 2 measurements of the first and second examiners.
Central corneal thickness measurements by the 3 methods, absolute difference of the first and second measurements by a single examiner, absolute difference of the 2 measurements by 2 examiners, and relative amount of variation.
The average measurements of central corneal thickness by a rotating Scheimpflug camera, scanning-slit topography, and ultrasonic pachymetry were 538+/-31.3 microm, 541+/-40.7 microm, and 545+/-31.3 microm, respectively. There were no statistically significant differences in the measurement results among the 3 methods (P = 0.569, repeated-measures analysis of variance). There was a significant linear correlation between the rotating Scheimpflug camera and ultrasonic pachymetry (r = 0.908, P<0.0001), rotating Scheimpflug camera and scanning-slit topography (r = 0.930, P<0.0001), and ultrasonic pachymetry and scanning-slit topography (r = 0.887, P<0.0001). Ultrasonic pachymetry had the smallest intraexaminer variability, and scanning-slit topography had the largest intraexaminer variability among the 3 methods. There were similar variations in interexaminer reproducibility among the 3 methods.
Mean corneal thicknesses were comparable among rotating Scheimpflug camera, ultrasonic pachymetry, and scanning-slit topography with the acoustic equivalent correction factor. The measurements of the 3 instruments had significant linear correlations with one another, and all methods had highly satisfactory measurement repeatability.
比较使用旋转式Scheimpflug相机、超声测厚仪以及扫描裂隙角膜地形图/测厚仪测量中央角膜厚度的结果及其可重复性。
实验研究。
64例受试者的74只眼，除白内障外无其他眼部异常。
对54例受试者的54只眼使用3种方法测量角膜厚度并进行比较。另外对5例受试者的10只眼，由同一名检查者对每种测厚方法重复测量2次，将首次和第二次测量的绝对差值作为检查者内重复性评估指标。对另外5例受试者的10只眼，由两名经验丰富的检查者对每种测厚方法各测量1次，将两名检查者测量结果的绝对差值作为检查者间可重复性评估指标。
3种方法测量的中央角膜厚度、同一名检查者首次和第二次测量的绝对差值、两名检查者测量结果的绝对差值以及变异的相对量。
旋转式Scheimpflug相机、扫描裂隙地形图及超声测厚仪测量中央角膜厚度的平均值分别为538±31.3μm、541±40.7μm和545±31.3μm。3种方法的测量结果之间无统计学显著差异（P = 0.569，重复测量方差分析）。旋转式Scheimpflug相机与超声测厚仪之间（r = 0.908，P<0.0001）、旋转式Scheimpflug相机与扫描裂隙地形图之间（r = 0.930，P<0.0001）以及超声测厚仪与扫描裂隙地形图之间（r = 0.887，P<0.0001）均存在显著的线性相关性。在3种方法中，超声测厚仪的检查者内变异性最小，扫描裂隙地形图的检查者内变异性最大。3种方法在检查者间可重复性方面的变异情况相似。
使用声学等效校正因子时，旋转式Scheimpflug相机、超声测厚仪和扫描裂隙地形图测量的平均角膜厚度具有可比性。3种仪器的测量结果之间具有显著的线性相关性，且所有方法的测量重复性均非常令人满意。
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