酪氨酸阻遏物对大肠杆菌中aroH的表达起负调控作用。
The tyrosine repressor negatively regulates aroH expression in Escherichia coli.
作者信息
Muday G K, Johnson D I, Somerville R L, Herrmann K M
机构信息
Department of Biochemistry, Purdue University, West Lafayette, Indiana 47907-6799.
出版信息
J Bacteriol. 1991 Jun;173(12):3930-2. doi: 10.1128/jb.173.12.3930-3932.1991.
Abstract
The levels of the tryptophan-sensitive isoenzyme of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase of Escherichia coli, encoded by the aroH gene, were elevated in tyrR and/or trpR mutants. The effect of tyrR and trpR lesions on aroH expression was confirmed by using a lacZ reporter system. The mutational elimination of either repressor led to a threefold increase in beta-galactosidase.
摘要
由aroH基因编码的大肠杆菌3-脱氧-D-阿拉伯庚酮糖酸-7-磷酸合酶的色氨酸敏感同工酶水平，在tyrR和/或trpR突变体中有所升高。通过使用lacZ报告系统，证实了tyrR和trpR损伤对aroH表达的影响。任一阻遏物的突变消除导致β-半乳糖苷酶增加了三倍。
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