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双侧眼眶黏膜相关淋巴组织淋巴瘤中肺炎衣原体的检测

Detection of Chlamydia pneumoniae in a bilateral orbital mucosa-associated lymphoid tissue lymphoma.

作者信息

Shen Defen, Yuen Hunter K L, Galita Dan A, Chan Nongnart R, Chan Chi-Chao

机构信息

Laboratory of Immunology, National Institutes of Health, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA.

出版信息

Am J Ophthalmol. 2006 Jun;141(6):1162-3. doi: 10.1016/j.ajo.2006.01.067.

DOI:10.1016/j.ajo.2006.01.067
PMID:16765702
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1934402/
Abstract

PURPOSE

To detect Chlamydia pneumoniae (C. pneumoniae) gene in a patient with bilateral orbital musoca-associated lymphoid tissue (MALT) lymphoma.

DESIGN

Interventional case report.

METHODS

A 47-year-old Chinese man with recurrent bilateral orbital masses underwent surgical biopsy. Ophthalmologic and radiographic examinations, routine histology, immunohistochemistry, and molecular analysis for immunoglobulin heavy chain (IgH), bcl-2/IgH gene translocation, and Chlamydia genes were performed.

RESULTS

Pathology revealed orbital MALT lymphoma with B-cell monoclonality. In addition to IgH gene rearrangement, C. pneumoniae DNA was detected in the lymphoma.

CONCLUSIONS

The finding of C. pneumoniae molecular signatures in this case suggests a possible association of Chlamydia and orbital MALT lymphoma. The infection may contribute to the development of the lymphoma.

摘要

目的

检测一名双侧眼眶黏膜相关淋巴组织（MALT）淋巴瘤患者的肺炎衣原体（C. pneumoniae）基因。

设计

介入性病例报告。

方法

一名47岁复发性双侧眼眶肿物的中国男性接受了手术活检。进行了眼科和影像学检查、常规组织学检查、免疫组织化学检查以及免疫球蛋白重链（IgH）、bcl-2/IgH基因易位和衣原体基因的分子分析。

结果

病理显示眼眶MALT淋巴瘤伴B细胞单克隆性。除IgH基因重排外，在淋巴瘤中检测到肺炎衣原体DNA。

结论

该病例中肺炎衣原体分子特征的发现提示衣原体与眼眶MALT淋巴瘤可能存在关联。这种感染可能促进淋巴瘤的发生。

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