氯喹对母乳中病毒载量的影响。
Impact of chloroquine on viral load in breast milk.
作者信息
Semrau Katherine, Kuhn Louise, Kasonde Prisca, Sinkala Moses, Kankasa Chipepo, Shutes Erin, Vwalika Cheswa, Ghosh Mrinal, Aldrovandi Grace, Thea Donald M
机构信息
Center for International Health & Development, Boston University School of Public Health, Boston, MA 02118, USA.
出版信息
Trop Med Int Health. 2006 Jun;11(6):800-3. doi: 10.1111/j.1365-3156.2006.01645.x.
The anti-malarial agent chloroquine has activity against HIV. We compared the effect of chloroquine (n = 18) to an anti-malarial agent without known anti-HIV-activity, sulfadoxine-pyrimethamine (n = 12), on breast milk HIV RNA levels among HIV-infected breastfeeding women in Zambia. After adjusting for CD4 count and plasma viral load, chloroquine was associated with a trend towards lower levels of HIV RNA in breast milk compared with sulfadoxine-pyrimethamine (P = 0.05). Higher breastmilk viral load was also observed among women receiving presumptive treatment for symptomatic malaria compared with asymptomatic controls and among controls reporting fever in the prior week. Further research is needed to determine the potential role of chloroquine in prevention of HIV transmission through breastfeeding.
抗疟药氯喹对HIV具有活性。我们在赞比亚的HIV感染哺乳期妇女中，比较了氯喹（n = 18）与一种无已知抗HIV活性的抗疟药磺胺多辛-乙胺嘧啶（n = 12）对母乳中HIV RNA水平的影响。在对CD4细胞计数和血浆病毒载量进行校正后，与磺胺多辛-乙胺嘧啶相比，氯喹与母乳中HIV RNA水平较低的趋势相关（P = 0.05）。与无症状对照组相比，接受有症状疟疾推定治疗的妇女以及在前一周报告发热的对照组中，母乳病毒载量也更高。需要进一步研究以确定氯喹在预防通过母乳喂养传播HIV方面的潜在作用。
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