Khanjani Narges, Sim Malcolm Ross
Centre for Occupational and Environmental Health, Department of Epidemiology and Preventive Medicine, Monash University, The Alfred Hospital, Commercial Road, Melbourne, VIC 3004, Australia.
Sci Total Environ. 2006 Sep 15;368(2-3):557-64. doi: 10.1016/j.scitotenv.2006.03.029. Epub 2006 Apr 27.
The effects of organochlorines on human reproduction have been recently under scrutiny. Some negative effects on animal reproduction have been reported. In this study we aimed to evaluate the effect of maternal contamination with a certain group of organochlorines, which are cyclodienes, HCB (hexachlorobenzene) and beta-BHC (beta-hexachlorocyclohexane) on human reproduction. Breast milk samples from 815 eligible Victorian mothers were used for measuring maternal contamination and the reproductive outcomes such as birth weight, head circumference and prematurity were taken from health files. Our study did not show any significant negative effect on outcomes such as birth weight, small for gestation age, previous miscarriage or still birth, head circumference or sex ratio. An inconsistent increase across oxychlordane exposure levels for prematurity was found. We also found an inverse association between the highest levels of HCB and oxychlordane with previous miscarriage or still birth; but this was based on small numbers and may be explained by loss of contaminants through the aborted fetus. These results suggest that the declining contamination levels of these chemicals do not impose a threat to human reproduction.
有机氯对人类生殖的影响最近受到了密切关注。已报道了其对动物生殖的一些负面影响。在本研究中，我们旨在评估母体受到某类有机氯（即环二烯、六氯苯（HCB）和β - 六氯环己烷（β - BHC））污染对人类生殖的影响。从815名符合条件的维多利亚州母亲那里采集母乳样本，用于测量母体污染情况，并从健康档案中获取出生体重、头围和早产等生殖结局数据。我们的研究未显示出对出生体重、小于胎龄儿、既往流产或死产、头围或性别比例等结局有任何显著的负面影响。发现早产情况随氧氯丹暴露水平呈不一致的增加。我们还发现，HCB和氧氯丹的最高水平与既往流产或死产之间存在负相关；但这是基于少量数据，可能是由于流产胎儿中污染物的流失所致。这些结果表明，这些化学物质污染水平的下降不会对人类生殖构成威胁。
