Dobson J, Villiers E, Roulois A, Gould S, Mellor P, Hoather T, Watson P
Department of Clinical Veterinary Medicine, The Queen's Veterinary School Hospital, University of Cambridge, Madingley Road, Cambridge CB3 0ES.
Vet Rec. 2006 Jun 17;158(24):825-9. doi: 10.1136/vr.158.24.825.
Three flat-coated retrievers with a regenerative anaemia were examined. They were hypoproteinaemic suggesting that the anaemia might be due to blood loss, but it was not possible to identify a site of haemorrhage. All three had splenomegaly with splenic abnormalities apparent on ultrasonography. Ultimately all three animals were shown to have a histiocytic sarcoma involving the spleen and other tissues. A fourth flat-coated retriever with anaemia, hypoproteinaemia and an abdominal mass was also diagnosed with a histiocytic sarcoma of the spleen following splenectomy. It is postulated that the dogs' anaemia was due to erythrophagocytosis, either directly by neoplastic cells or by reactive macrophages.
对三只患有再生性贫血的平毛寻回犬进行了检查。它们存在低蛋白血症，提示贫血可能是由于失血所致，但无法确定出血部位。所有三只犬均有脾肿大，超声检查显示脾脏有异常。最终，所有三只动物均被证实患有累及脾脏和其他组织的组织细胞肉瘤。第四只患有贫血、低蛋白血症和腹部肿块的平毛寻回犬在脾切除术后也被诊断为脾脏组织细胞肉瘤。据推测，这些犬的贫血是由于肿瘤细胞或反应性巨噬细胞直接吞噬红细胞所致。
