Soare T, Noble P-J, Hetzel U, Fonfara S, Kipar A
Department of Veterinary Pathology, School of Veterinary Science, University of Liverpool, Crown Street, Liverpool L69 7ZJ, UK.
J Comp Pathol. 2012 Feb-Apr;146(2-3):168-74. doi: 10.1016/j.jcpa.2011.05.006. Epub 2011 Jul 7.
A case of metastatic splenic haemophagocytic histiocytic sarcoma (HHS) in a 6-year-old neutered male flat-coated retriever is described. The main clinical findings were hypoalbuminaemia and regenerative anaemia. The diagnosis was based on histological features and expression of CD11d by the neoplastic cells. Tumour cells were shown to produce interleukin (IL)-6, to phagocytose erythrocytes and to take up albumin, as demonstrated by immunohistochemistry and ultrastructural examination. Quantitative polymerase chain reaction identified increased IL-6 gene expression in affected organs. These findings suggest that neoplastic cells are responsible for the clinical features of HHS, by removing erythrocytes and albumin from the blood and releasing cytokines, such as IL-6.
本文描述了一例6岁绝育雄性平毛寻回犬转移性脾噬血细胞性组织细胞肉瘤（HHS）。主要临床症状为低白蛋白血症和再生性贫血。诊断基于组织学特征以及肿瘤细胞CD11d的表达。免疫组织化学和超微结构检查显示，肿瘤细胞可产生白细胞介素（IL）-6、吞噬红细胞并摄取白蛋白。定量聚合酶链反应确定了患病器官中IL-6基因表达增加。这些发现表明，肿瘤细胞通过从血液中清除红细胞和白蛋白并释放细胞因子（如IL-6），导致了HHS的临床症状。
