Locascio Laurie E, Ross David J, Howell Peter B, Gaitan Michael
Analytical Chemistry Division, National Institute of Standards and Technology, Gaithersburg, MD, USA.
Methods Mol Biol. 2006;339:37-46. doi: 10.1385/1-59745-076-6:37.
Fabrication of microfluidic channels in common commercially available thermoplastic materials can be easily accomplished using hot embossing or ultraviolet (UV) laser ablation. Hot embossing involves replication of a microfluidic network in a polymer substrate from a stamp (or template) fabricated in silicon or metal. UV laser ablation is performed by either exposing the polymer substrate through a mask or by using a laser direct-write process. The resulting polymer microfluidic channels are most often sealed with another polymer piece using thermal bonding or solvent bonding to complete the fabrication procedure. Unlike their silicon and glass counterparts, polymer microfluidic systems can be fabricated by these methods in less than 1 h, making the materials attractive for both research prototyping and commercialization.
使用热压印或紫外（UV）激光烧蚀，可以轻松地在常见的市售热塑性材料中制造微流体通道。热压印涉及从硅或金属制成的印章（或模板）在聚合物基板中复制微流体网络。UV激光烧蚀是通过掩膜曝光聚合物基板或使用激光直写工艺来进行的。所得的聚合物微流体通道最常使用热键合或溶剂键合与另一个聚合物片密封，以完成制造过程。与硅和玻璃制成的微流体系统不同，聚合物微流体系统可以通过这些方法在不到1小时内制造出来，这使得这些材料对研究原型制作和商业化都具有吸引力。
