Wang Yue, Pot David, Kachman Stephen D, Nuzhdin Sergey V, Harshman Lawrence G
Department of Statistics, University of Nebraska-Lincoln, Lincoln, NE 68583-0963, USA.
J Hered. 2006 Jul-Aug;97(4):355-66. doi: 10.1093/jhered/esl009. Epub 2006 Jun 22.
Little is known about natural genetic variation for survival under oxidative stress conditions or whether genetic variation for oxidative stress survival is associated with that for life-history traits. We have investigated survival in a high-oxygen environment at 2 adult densities using a set of recombinant inbred lines (RILs) isolated from a natural population of Drosophila melanogaster. Female and male oxidative stress survival was highly correlated. Quantitative trait loci (QTLs) for oxidative stress survival were identified on both autosomes. These QTLs were sometimes sex or density specific but were most often not. QTLs were identified that colocalize to the same region of the genome as longevity in other studies using the same set of RILs. We also determined early-age egg production and found QTLs for this trait, but there was no support for an association between oxidative stress survival and egg production.
对于氧化应激条件下生存的自然遗传变异，或者氧化应激生存的遗传变异是否与生活史特征的遗传变异相关，我们知之甚少。我们使用从黑腹果蝇自然种群中分离出的一组重组近交系（RIL），在2种成虫密度下研究了在高氧环境中的生存情况。雌性和雄性氧化应激生存高度相关。在两条常染色体上都鉴定出了氧化应激生存的数量性状位点（QTL）。这些QTL有时具有性别或密度特异性，但大多数情况下并非如此。在其他使用同一组RIL的研究中，发现了与长寿共定位于基因组同一区域的QTL。我们还测定了早期产卵量，并发现了该性状的QTL，但没有证据支持氧化应激生存与产卵量之间存在关联。
