Luo Hai-Dong, Gazzard Gus, Fong Allan, Aung Tin, Hoh Sek Tien, Loon Seng-Chee, Healey Paul, Tan Donald T H, Wong Tien-Yin, Saw Seang-Mei
Singapore Eye Research Institute, and Department of Community, Occupational and Family Medicine, National University of Singapore, Republic of Singapore.
Invest Ophthalmol Vis Sci. 2006 Jul;47(7):2773-81. doi: 10.1167/iovs.05-1380.
The purpose of this study was to evaluate the associations between macular volume and thickness, as assessed by optic coherence tomography (OCT), with refraction and axial length (AL) in children.
A total of 104 Chinese school children (51 girls and 53 boys) 11 to 12 years of age were randomly selected from one school during the 2005 examination in the Singapore Cohort Study of the Risk Factors for Myopia (SCORM). Cycloplegic autorefraction was performed to obtain refraction (defined as spherical equivalent [SE]) and ultrasound biometry performed to obtain the AL. Macular volume and thickness were then measured (StratusOCT3; Carl Zeiss Meditec, Dublin, CA).
Children with moderate myopia (SE at least -3.0 D) tended to have smaller total macular volume and thinner quadrant-specific macular thickness (except in the inferior and superior inner quadrants), followed by children with low myopia (-0.5<or=SE<-3.0 D), compared with children with no myopia (SE>-0.5 D). Total macular volume was positively associated with SE (beta=1.58, 95% CI, 0.84 to 2.32, standardized beta=0.14, P<0.001) and negatively associated with AL (beta=-1.20, 95% CI, -1.62 to -0.79, standardized beta=0.45, P<0.001) in multiple linear regression models controlling for age and gender.
In children, increasing axial myopia was associated with reduced macular volume and thickness. These findings suggest that early anatomic changes may be present in the retinas of children with axial myopia.
本研究旨在评估通过光学相干断层扫描（OCT）测量的黄斑体积和厚度与儿童屈光及眼轴长度（AL）之间的关联。
在新加坡近视危险因素队列研究（SCORM）2005年的检查期间，从一所学校随机选取了104名11至12岁的中国学龄儿童（51名女孩和53名男孩）。进行睫状肌麻痹验光以获得屈光度数（定义为等效球镜度[SE]），并进行超声生物测量以获得眼轴长度。然后测量黄斑体积和厚度（StratusOCT3；卡尔·蔡司医疗技术公司，加利福尼亚州都柏林）。
与无近视儿童（SE > -0.5 D）相比，中度近视儿童（SE至少为 -3.0 D）的黄斑总体积往往较小，象限特异性黄斑厚度较薄（下内象限和上内象限除外），其次是低度近视儿童（-0.5≤SE < -3.0 D）。在控制年龄和性别的多元线性回归模型中，黄斑总体积与SE呈正相关（β = 1.58，95% CI，0.84至2.32，标准化β = 0.14，P < 0.001），与眼轴长度呈负相关（β = -1.20，95% CI，-1.62至 -0.79，标准化β = 0.45，P < 0.001）。
在儿童中，轴性近视增加与黄斑体积和厚度减小有关。这些发现表明，轴性近视儿童的视网膜可能存在早期解剖学变化。
