Bronnick K, Ehrt U, Emre M, De Deyn P P, Wesnes K, Tekin S, Aarsland D
Psychiatric Clinic, Stavanger University Hospital, Helse Stavanger, Post Box 8100, 4068 Stavanger, Norway.
J Neurol Neurosurg Psychiatry. 2006 Oct;77(10):1136-42. doi: 10.1136/jnnp.2006.093146. Epub 2006 Jun 26.
To investigate the effects of attentional deficits on activities of daily living (ADL) in patients with dementia associated with Parkinson's disease (PDD).
461 patients were assessed neuropsychologically. Factor analyses were used to differentiate attention from other cognitive functions and to differentiate different aspects of ADL functions. The effects of the attentional measure on ADL were examined using sequential multiple regression, controlling for age, sex, education, severity of motor symptoms and other cognitive functions.
Three cognitive factors were identified, with one factor emerging as a measure of vigilance and focused attention. This factor predicted different aspects of ADL status even after controlling for motor functions and other cognitive factors. The attention factor was the single strongest cognitive predictor of ADL status, matching the strength of the effects of motor functions on ADL status.
Impaired attention is an important determinant of ADL functions in patients with PDD.
探讨注意力缺陷对帕金森病伴发痴呆（PDD）患者日常生活活动（ADL）的影响。
对461例患者进行神经心理学评估。采用因素分析将注意力与其他认知功能区分开来，并区分ADL功能的不同方面。使用逐步多元回归分析注意力测量对ADL的影响，同时控制年龄、性别、教育程度、运动症状严重程度和其他认知功能。
确定了三个认知因素，其中一个因素作为警觉性和集中注意力的测量指标出现。即使在控制了运动功能和其他认知因素之后，该因素仍能预测ADL状态的不同方面。注意力因素是ADL状态最强的单一认知预测指标，与运动功能对ADL状态的影响强度相当。
注意力受损是PDD患者ADL功能的重要决定因素。
