Jansen W T M, van der Bruggen J T, Verhoef J, Fluit A C
Eijkman-Winkler Institute, University Medical Center Utrecht, UMCU G04-614, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.
Drug Resist Updat. 2006 Jun;9(3):123-33. doi: 10.1016/j.drup.2006.06.002. Epub 2006 Jun 27.
The development of antimicrobial agents has been a key achievement of modern medicine. However, their overuse has led to an increasing incidence of infections due to antibiotic-resistant microorganisms. Quantitative figures on the current economic and health impact of antimicrobial resistance are scant, but it is clearly a growing challenge that requires timely action. That action should be at the educational, ethical, economic and political level. An important first step would be to increase public awareness and willingness to take the necessary measures to curb resistance. Hence, studies are needed that would provide solid, quantitative data on the societal impact of antibiotic resistance. This review discusses the complexity of resistance, identifies its main drivers and proposes measures to contain it on a European scale.
抗菌药物的研发是现代医学的一项关键成就。然而，其过度使用导致了由抗生素耐药微生物引起的感染发病率不断上升。关于抗菌药物耐药性当前的经济和健康影响的定量数据很少，但这显然是一个日益严峻的挑战，需要及时采取行动。这种行动应在教育、伦理、经济和政治层面展开。重要的第一步是提高公众意识以及采取必要措施遏制耐药性的意愿。因此，需要开展相关研究，以提供关于抗生素耐药性社会影响的可靠定量数据。本综述讨论了耐药性的复杂性，确定了其主要驱动因素，并提出了在欧洲范围内控制耐药性的措施。
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