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乳腺钼靶筛查假阳性结果引发的女性焦虑:一项条件价值评估调查

Women's anxieties caused by false positives in mammography screening: a contingent valuation survey.

作者信息

Yasunaga Hideo, Ide Hiroo, Imamura Tomoaki, Ohe Kazuhiko

机构信息

Department of Planning, Information, and Management, University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

出版信息

Breast Cancer Res Treat. 2007 Jan;101(1):59-64. doi: 10.1007/s10549-006-9270-4. Epub 2006 Jul 4.

Abstract

BACKGROUND

Breast cancer screening with mammography has been shown to be effective for preventing breast cancer death. However, mammography screening can be harmful to women. One of the major problems is anxiety from a false positive result. Previous studies do not consider intangible benefits related to anxiety or peace of mind in mammography screening. In order to quantify anxiety, we employed the contingent valuation method (CVM) to measure the general public's willingness to pay (WTP) for mammography screening.

METHODS

About 397 women aged 50-59 participated in the computer-assisted questionnaire survey. For the WTP question format, the double-bound dichotomous choice approach was employed. Participants were randomly assigned into 2 groups. Group A (n = 200) was provided with information about the procedure, detection rate and mortality reduction of mammography screening. Group B (n = 197) was provided with additional information including possibility of false positives and the risks of close examinations.

RESULTS

The mean WTP was significantly greater in Group A than in Group B ($16.82 vs. $12.89, P = 0.02). A Weibull regression analysis showed that, type of information, history of receiving mammography screening, family history of cancer, and the degree of concern about health were significant factors affecting WTP.

CONCLUSIONS

Women must be well informed before making decisions about mammography screening. Although anxiety from information about false positives significantly decreased the women's benefit, the amount of WTP in the well-informed group was still considerable. The results suggest that women can balance the anxiety against the effectiveness.

摘要

背景

乳腺钼靶筛查已被证明对预防乳腺癌死亡有效。然而,乳腺钼靶筛查可能对女性有害。主要问题之一是假阳性结果导致的焦虑。以往的研究没有考虑乳腺钼靶筛查中与焦虑或安心相关的无形益处。为了量化焦虑,我们采用条件价值评估法(CVM)来衡量公众对乳腺钼靶筛查的支付意愿(WTP)。

方法

约397名年龄在50 - 59岁的女性参与了计算机辅助问卷调查。对于支付意愿问题格式,采用了双边界二分选择法。参与者被随机分为两组。A组(n = 200)被告知乳腺钼靶筛查的程序、检测率和死亡率降低情况。B组(n = 197)还被告知包括假阳性可能性和进一步检查风险等额外信息。

结果

A组的平均支付意愿显著高于B组(16.82美元对12.89美元,P = 0.02)。威布尔回归分析表明,信息类型、接受乳腺钼靶筛查的历史、癌症家族史以及对健康的关注程度是影响支付意愿的显著因素。

结论

女性在决定是否进行乳腺钼靶筛查之前必须充分了解相关信息。虽然关于假阳性的信息导致的焦虑显著降低了女性的受益,但信息充分组的支付意愿金额仍然可观。结果表明女性可以在焦虑与有效性之间取得平衡。

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