一项比较类固醇与环孢素局部治疗口腔扁平苔藓的随机对照试验。
A randomized controlled trial to compare steroid with cyclosporine for the topical treatment of oral lichen planus.
作者信息
Yoke Poon Choy, Tin Goh Bee, Kim Myung-Jin, Rajaseharan Annabelle, Ahmed Shaheen, Thongprasom Kobkan, Chaimusik Mantharop, Suresh Shirley, Machin David, Bee Wong Hwee, Seldrup Jorgen
机构信息
Department of Oral and Maxillofacial Surgery, National Dental Center, Singapore.
出版信息
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006 Jul;102(1):47-55. doi: 10.1016/j.tripleo.2005.09.006. Epub 2006 Mar 24.
OBJECTIVE
To compare the effectiveness of cyclosporine solution versus triamcinolone acetonide in orabase in the treatment of oral lichen planus (OLP) in reducing signs and symptoms.
STUDY DESIGN
One hundred thirty-nine biopsy-proven OLP patients were randomly assigned to cyclosporine (68) or steroid (71) applied onto the target lesion and affected areas. Assessments were at weeks 0, 2, 4, 8 by clinical scoring and grid measurement of the target lesion (reticulation, erythema, ulceration). Patients ranked severity of pain and burning sensation using visual analog scales.
RESULTS
Although clinical response, pain, burning sensation, area of reticulation, erythema, and ulceration at week 4 were all worse in patients receiving cyclosporine than in those receiving steroid, the differences were not statistically significant. Large patient-to-patient variability was evident over the observation period, with little evidence of marked changes in levels over time in both treatment groups.
CONCLUSION
Topical cyclosporine appears no more effective than steroid in the treatment of oral lichen planus.
目的
比较环孢素溶液与曲安奈德口腔糊剂治疗口腔扁平苔藓（OLP）在减轻体征和症状方面的有效性。
研究设计
139例经活检证实的OLP患者被随机分为两组，分别在靶病变及受累区域应用环孢素（68例）或类固醇（71例）。在第0、2、4、8周通过临床评分和对靶病变（网状、红斑、溃疡）进行网格测量来评估。患者使用视觉模拟量表对疼痛和烧灼感的严重程度进行评分。
结果
尽管在第4周时，接受环孢素治疗的患者在临床反应、疼痛、烧灼感、网状、红斑及溃疡面积方面均比接受类固醇治疗的患者差，但差异无统计学意义。在观察期内，患者个体间差异明显，两个治疗组中均未发现随时间推移水平有明显变化的证据。
结论
局部应用环孢素在治疗口腔扁平苔藓方面似乎并不比类固醇更有效。
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