Nuwagaba-Biribonwoha H, Mayon-White R T, Okong P, Carpenter L M, Jenkinson C
Medical Research Council, Clinical Trials Unit (MRC-CTU), London, UK.
AIDS Care. 2006 Aug;18(6):614-20. doi: 10.1080/09540120500359298.
To study the effect of HIV infection on quality of life (QOL) during pregnancy and puerperium, QOL was measured in a cohort study at St. Francis Hospital Nsambya, Kampala, Uganda. Dartmouth COOP charts were administered to 132 HIV-positive and 399 HIV-negative women at 36 weeks of pregnancy and six weeks post-partum. Responses were coded from 0 = best health-status to 4 = worst health-status and scores of 3-4 defined as poor. Odds ratios (OR) (95% confidence intervals(CI)) for poor scores were calculated and independent predictors of poor QOL examined using logistic regression. In pregnancy, HIV-positive women were more likely to have poor scores in feelings: OR = 3.2(1.9-5.3), daily activities: OR = 2.8(1.4-5.5), pain: OR = 2.1(1.3-3.5), overall health: OR = 1.7(1.1-2.7) and QOL: OR = 7.2(3.6-14.7), all p= <or= 0.01. Differences in physical fitness, change in health, social activities and social support were not statistically significant (all p>0.2). HIV infection was independently associated with poor QOL: OR = 8.5(3.8-19). Findings in puerperium were similar to those in pregnancy except more HIV-positive women had poor scores in social activities: OR = 2.5(1.4-4.7) and change in health: OR = 5.4(2-14.5) and infant death also predicted poor QOL: OR = 6.7(2.4-18.5). The findings reflect HIV's adverse impact on maternal QOL and the need for interventions to alleviate this infection's social and emotional effects.
为研究艾滋病毒感染对孕期及产褥期生活质量（QOL）的影响，在乌干达坎帕拉市圣弗朗西斯医院恩桑比亚分院开展的一项队列研究中对生活质量进行了测量。在妊娠36周和产后6周时，对132名艾滋病毒阳性和399名艾滋病毒阴性女性发放了达特茅斯合作图表。回答从0 = 最佳健康状况编码至4 = 最差健康状况，得分3 - 4被定义为差。计算了差得分的比值比（OR）（95%置信区间（CI）），并使用逻辑回归分析了生活质量差的独立预测因素。在孕期，艾滋病毒阳性女性在情感方面更易出现差得分：OR = 3.2（1.9 - 5.3），日常活动方面：OR = 2.8（1.4 - 5.5），疼痛方面：OR = 2.1（1.3 - 3.5），总体健康方面：OR = 1.7（1.1 - 2.7）以及生活质量方面：OR = 7.2（3.6 - 14.7），所有p≤0.01。在身体素质、健康变化、社交活动和社会支持方面的差异无统计学意义（所有p>0.2）。艾滋病毒感染与生活质量差独立相关：OR = 8.5（3.8 - 19）。产褥期的结果与孕期相似，只是更多艾滋病毒阳性女性在社交活动方面得分差：OR = 2.5（1.4 - 4.7），健康变化方面：OR = 5.4（2 - 14.5），并且婴儿死亡也预示着生活质量差：OR = 6.7（2.4 - 18.5）。这些发现反映了艾滋病毒对孕产妇生活质量的不利影响以及采取干预措施减轻这种感染的社会和情感影响的必要性。
