Barbiéri C L
Division of Parasitology, Department of Immunology, Microbiology and Parasitology, Universidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo, SP, Brazil.
Parasite Immunol. 2006 Jul;28(7):329-37. doi: 10.1111/j.1365-3024.2006.00840.x.
The role of dogs as the main reservoir of visceral leishmaniasis has led to an increased interest in the immune responses and in Leishmania antigens implicated in protective cellular immunity in canine visceral leishmaniasis. The primary goal is to control the prevalence of human disease. Immune responses in canine visceral leishmaniasis are reviewed. Cellular immune responses toward a Th1 subset mediated by IFN-gamma and TNF-alpha predominate in asymptomatic dogs exhibiting apparent resistance to visceral leishmaniasis. On the other hand, while the role of Th2 cytokines, such as IL-4 and IL-10, in symptomatic animals is still controversial, there is increasing evidence for a correlation of these cytokines with progressive disease. CD8+ cytotoxic T cells seem also likely to be involved in resistance to visceral leishmaniasis. Several Leishmania antigens implicated in protective immune responses are described and some pivotal points for development of an effective vaccine against canine visceral leishmaniasis are discussed.
狗作为内脏利什曼病主要储存宿主的作用，引发了人们对犬内脏利什曼病免疫反应以及与保护性细胞免疫相关的利什曼原虫抗原的更多关注。主要目标是控制人类疾病的流行率。本文综述了犬内脏利什曼病的免疫反应。在对内脏利什曼病表现出明显抵抗力的无症状犬中，由干扰素-γ和肿瘤坏死因子-α介导的针对Th1亚群的细胞免疫反应占主导。另一方面，虽然Th2细胞因子如白细胞介素-4和白细胞介素-10在有症状动物中的作用仍存在争议，但越来越多的证据表明这些细胞因子与疾病进展相关。CD8 + 细胞毒性T细胞似乎也可能参与对内脏利什曼病的抵抗。文中描述了几种与保护性免疫反应相关的利什曼原虫抗原，并讨论了开发针对犬内脏利什曼病有效疫苗的一些关键点。
