DISULFIND：一种二硫键结合状态和半胱氨酸连接性预测服务器。

DISULFIND: a disulfide bonding state and cysteine connectivity prediction server.

作者信息

Ceroni Alessio, Passerini Andrea, Vullo Alessandro, Frasconi Paolo

机构信息

Machine Learning and Neural Networks Group, Università degli Studi di Firenze, Dipartimento di Sistemi e Informatica, Via di Santa Marta 3, 50139 Firenze, Italy.

出版信息

Nucleic Acids Res. 2006 Jul 1;34(Web Server issue):W177-81. doi: 10.1093/nar/gkl266.

DOI:10.1093/nar/gkl266

PMID:16844986

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1538823/

Abstract

DISULFIND is a server for predicting the disulfide bonding state of cysteines and their disulfide connectivity starting from sequence alone. Optionally, disulfide connectivity can be predicted from sequence and a bonding state assignment given as input. The output is a simple visualization of the assigned bonding state (with confidence degrees) and the most likely connectivity patterns. The server is available at http://disulfind.dsi.unifi.it/.

摘要

DISULFIND是一个服务器，仅从序列开始预测半胱氨酸的二硫键结合状态及其二硫键连接性。可选择地，二硫键连接性可以根据输入的序列和给定的结合状态分配来预测。输出是分配的结合状态（带有置信度）和最可能的连接模式的简单可视化。该服务器可在http://disulfind.dsi.unifi.it/获取。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7d0/1538823/c839d52e9ed0/gkl266f1.jpg

相似文献

DISULFIND: a disulfide bonding state and cysteine connectivity prediction server.

Nucleic Acids Res. 2006 Jul 1;34(Web Server issue):W177-81. doi: 10.1093/nar/gkl266.

DiANNA 1.1: an extension of the DiANNA web server for ternary cysteine classification.

Nucleic Acids Res. 2006 Jul 1;34(Web Server issue):W182-5. doi: 10.1093/nar/gkl189.

Disulfide connectivity prediction using recursive neural networks and evolutionary information.

Bioinformatics. 2004 Mar 22;20(5):653-9. doi: 10.1093/bioinformatics/btg463. Epub 2004 Jan 22.

Cysteine separations profiles on protein sequences infer disulfide connectivity.

Bioinformatics. 2005 Apr 15;21(8):1415-20. doi: 10.1093/bioinformatics/bti179. Epub 2004 Dec 7.

A simplified approach to disulfide connectivity prediction from protein sequences.

BMC Bioinformatics. 2008 Jan 14;9:20. doi: 10.1186/1471-2105-9-20.

DBCP: a web server for disulfide bonding connectivity pattern prediction without the prior knowledge of the bonding state of cysteines.

Nucleic Acids Res. 2010 Jul;38(Web Server issue):W503-7. doi: 10.1093/nar/gkq514. Epub 2010 Jun 8.

Predicting disulfide connectivity from protein sequence using multiple sequence feature vectors and secondary structure.

Bioinformatics. 2007 Dec 1;23(23):3147-54. doi: 10.1093/bioinformatics/btm505. Epub 2007 Oct 17.

DiANNA: a web server for disulfide connectivity prediction.

Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W230-2. doi: 10.1093/nar/gki412.

Prediction of disulfide connectivity from protein sequences.

Proteins. 2005 Nov 15;61(3):507-12. doi: 10.1002/prot.20627.

CysView: protein classification based on cysteine pairing patterns.

Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W350-5. doi: 10.1093/nar/gkh475.

引用本文的文献

Unveiling the Immunostimulatory Potential of the HSPA1A Mini-Chaperones Compared to the HSPA1A and HSP27 Chaperones: In Silico and In Vitro Insights for Vaccine Development.

Protein J. 2025 Aug 14. doi: 10.1007/s10930-025-10285-6.

Synthesis of U-theraphotoxin-Pv1a_1, an larvicidal disulfide bridged peptide from the Colombian tarantula (Araneae: Theraphosidae).

Toxicon X. 2025 May 1;26:100224. doi: 10.1016/j.toxcx.2025.100224. eCollection 2025 Jun.

AlphaLasso-a web server to identify loop and lasso motifs in 3D structure of biopolymers.

Nucleic Acids Res. 2025 Jul 7;53(W1):W11-W19. doi: 10.1093/nar/gkaf375.

Molecular characterization and bioinformatic analysis of SGU protein in Anopheles culicifacies as target for transmission blocking activity.

Immunol Res. 2025 Jan 15;73(1):34. doi: 10.1007/s12026-024-09561-x.

Identification and expression analysis of Th2 immune-related gene IL4/13A in turbot ().

Front Immunol. 2024 Dec 3;15:1500840. doi: 10.3389/fimmu.2024.1500840. eCollection 2024.

The Leader of the Capsid (LC) Protein Contains a Putative Transmembrane Domain, Binds to the Cytoplasmic Membrane, and Exogenously Permeates Cells.

Viruses. 2024 Aug 19;16(8):1319. doi: 10.3390/v16081319.

A trimeric glycosylated GH45 cellulase from the red abalone (Haliotis rufescens) exhibits endo and exoactivity.

PLoS One. 2024 Apr 18;19(4):e0301604. doi: 10.1371/journal.pone.0301604. eCollection 2024.

Up Front Unfolded Protein Response Combined with Early Protein Secretion Pathway Engineering in to Attenuate ER Stress Caused by Enzyme Overproduction.

Int J Mol Sci. 2023 Nov 17;24(22):16426. doi: 10.3390/ijms242216426.

Hard nut to crack: Solving the disulfide linkage pattern of the Neosartorya (Aspergillus) fischeri antifungal protein 2.

Protein Sci. 2023 Jul;32(7):e4692. doi: 10.1002/pro.4692.

TapA acts as specific chaperone in TasA filament formation by strand complementation.

Proc Natl Acad Sci U S A. 2023 Apr 25;120(17):e2217070120. doi: 10.1073/pnas.2217070120. Epub 2023 Apr 17.

本文引用的文献

Large-scale prediction of disulphide bridges using kernel methods, two-dimensional recursive neural networks, and weighted graph matching.

Proteins. 2006 Mar 15;62(3):617-29. doi: 10.1002/prot.20787.

Improving disulfide connectivity prediction with sequential distance between oxidized cysteines.

Bioinformatics. 2005 Dec 15;21(24):4416-9. doi: 10.1093/bioinformatics/bti715. Epub 2005 Oct 13.

SCRATCH: a protein structure and structural feature prediction server.

Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W72-6. doi: 10.1093/nar/gki396.

DiANNA: a web server for disulfide connectivity prediction.

Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W230-2. doi: 10.1093/nar/gki412.

Disulfide connectivity prediction using secondary structure information and diresidue frequencies.

Bioinformatics. 2005 May 15;21(10):2336-46. doi: 10.1093/bioinformatics/bti328. Epub 2005 Mar 1.

Cysteine separations profiles on protein sequences infer disulfide connectivity.

Bioinformatics. 2005 Apr 15;21(8):1415-20. doi: 10.1093/bioinformatics/bti179. Epub 2004 Dec 7.

CysView: protein classification based on cysteine pairing patterns.

Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W350-5. doi: 10.1093/nar/gkh475.

The PredictProtein server.

Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W321-6. doi: 10.1093/nar/gkh377.

Prediction of disulfide-bonded cysteines in proteomes with a hidden neural network.

Proteomics. 2004 Jun;4(6):1665-71. doi: 10.1002/pmic.200300745.

Prediction of the disulfide-bonding state of cysteines in proteins based on dipeptide composition.

Biochem Biophys Res Commun. 2004 May 21;318(1):142-7. doi: 10.1016/j.bbrc.2004.03.189.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验

DISULFIND：一种二硫键结合状态和半胱氨酸连接性预测服务器。

DISULFIND: a disulfide bonding state and cysteine connectivity prediction server.

作者信息

机构信息

出版信息

相似文献

引用本文的文献

本文引用的文献

文献AI研究员

用中文搜PubMed

文档翻译

Suppr 超能文献

DISULFIND：一种二硫键结合状态和半胱氨酸连接性预测服务器。

DISULFIND: a disulfide bonding state and cysteine connectivity prediction server.

作者信息

机构信息

出版信息

相似文献

引用本文的文献

本文引用的文献