Wang C C, Chu M L, Ho L J, Hwang R C
Graduate Institute of Medical Sciences, Tri-Service General Hospital, Taipei, Taiwan, Republic of China.
J Hosp Infect. 1991 Sep;19(1):33-40. doi: 10.1016/0195-6701(91)90126-s.
Sequential outbreaks of nosocomial infection due to multiply-resistant Enterobacter cloacae occurred in September 1987, and between December 1988 and January 1989, in a paediatric intensive care unit. A total of eight neonates were affected and most had received ventilatory support. Initially, we were unable to determine whether the two outbreaks were caused by the same strain of E. cloacae. After applying plasmid profile analysis to identify epidemic strains, we established that the strain from the first outbreak was different from the second outbreak strain, as each had its own plasmid pattern. During the second outbreak, an environmental bacteriological survey was carried out. We found that the distilled water containers were contaminated with E. cloacae which had the same plasmid profile. After changing the distilled water containers and by reinforcement of aseptic techniques, the nosocomial outbreak was terminated.
1987年9月以及1988年12月至1989年1月期间，一家儿科重症监护病房发生了由多重耐药阴沟肠杆菌引起的医院感染连续暴发。共有8名新生儿受到影响，大多数接受了通气支持。最初，我们无法确定这两次暴发是否由同一株阴沟肠杆菌引起。在应用质粒图谱分析来鉴定流行菌株后，我们确定第一次暴发的菌株与第二次暴发的菌株不同，因为它们各自有自己的质粒模式。在第二次暴发期间，进行了一次环境细菌学调查。我们发现蒸馏水容器被具有相同质粒图谱的阴沟肠杆菌污染。更换蒸馏水容器并加强无菌技术后，医院感染暴发得以终止。
